Evidence map›Paper›PMID 37416090›Full record

ArticleNorth American Spine Society journal2023

Neuroplasticity and regeneration after spinal cord injury.

Nayaab Punjani, Dylan Deska-Gauthier, Laureen D Hachem, Madlene Abramian, Michael G Fehlings

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in North American Spine Society journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Nayaab PunjaniDivision of Genetics and Development, Krembil Research Institute, University Health Network, Toronto, ON, Canada.
Dylan Deska-GauthierDivision of Genetics and Development, Krembil Research Institute, University Health Network, Toronto, ON, Canada.
Laureen D HachemDivision of Genetics and Development, Krembil Research Institute, University Health Network, Toronto, ON, Canada.
Madlene AbramianDivision of Genetics and Development, Krembil Research Institute, University Health Network, Toronto, ON, Canada.
Michael G FehlingsDivision of Genetics and Development, Krembil Research Institute, University Health Network, Toronto, ON, Canada.
University Health Network · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal cord injury (SCI) is a debilitating condition with significant personal, societal, and economic burden. The highest proportion of traumatic injuries occur at the cervical level, which results in severe sensorimotor and autonomic deficits. Following the initial physical damage associated with traumatic injuries, secondary pro-inflammatory, excitotoxic, and ischemic cascades are initiated further contributing to neuronal and glial cell death. Additionally, emerging evidence has begun to reveal that spinal interneurons undergo subtype specific neuroplastic circuit rearrangements in the weeks to months following SCI, contributing to or hindering functional recovery. The current therapeutic guidelines and standards of care for SCI patients include early surgery, hemodynamic regulation, and rehabilitation. Additionally, preclinical work and ongoing clinical trials have begun exploring neuroregenerative strategies utilizing endogenous neural stem/progenitor cells, stem cell transplantation, combinatorial approaches, and direct cell reprogramming. This review will focus on emerging cellular and noncellular regenerative therapies with an overview of the current available strategies, the role of interneurons in plasticity, and the exciting research avenues enhancing tissue repair following SCI.

Indexed as

Early surgical decompressionNeural stem cellsNeuroplasticityNeuroregenerationRehabilitationSpinal cord injurySpinal interneurons

Identifiers

PMID37416090
PMCPMC10320621
OpenAlexW4379878263

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.