Modeling biological individuality using machine learning: A study on human gait.

Human gait is a complex and unique biological process that can offer valuable insights into an individual's health and well-being. In this work, we leverage a machine learning-based approach to model individual gait signatures and identify factors contributing to inter-individual variability in gait patterns. We provide a comprehensive analysis of gait individuality by (1) demonstrating the uniqueness of gait signatures in a large-scale dataset and (2) highlighting the gait characteristics that are most distinctive to each individual. We utilized the data from three publicly available datasets comprising 5368 bilateral ground reaction force recordings during level overground walking from 671 distinct healthy individuals. Our results show that individuals can be identified with a prediction accuracy of 99.3% by using the bilateral signals of all three ground reaction force components, with only 10 out of 1342 recordings in our test data being misclassified. This indicates that the combination of bilateral ground reaction force signals with all three components provides a more comprehensive and accurate representation of an individual's gait signature. The highest accuracy was achieved by (linear) Support Vector Machines (99.3%), followed by Random Forests (98.7%), Convolutional Neural Networks (95.8%), and Decision Trees (82.8%). The proposed approach provides a powerful tool to better understand biological individuality and has potential applications in personalized healthcare, clinical diagnosis, and therapeutic interventions.