Evidence map›Paper›PMID 37415987›Full record

ArticleFrontiers in immunology2023

The role of interleukin-18 and interleukin-18 binding protein in K/BxN serum transfer-induced arthritis.

Sebastien Fauteux-Daniel, Laura M Merlo Pich, Charlotte Girard-Guyonvarc'h, Assunta Caruso, Emiliana Rodriguez, Cem Gabay

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sebastien Fauteux-DanielDivision of Rheumatology, Department of Medicine, Geneva University Hospitals, Geneva, Switzerland.
Laura M Merlo PichDivision of Rheumatology, Department of Medicine, Geneva University Hospitals, Geneva, Switzerland.
Charlotte Girard-Guyonvarc'hDivision of Rheumatology, Department of Medicine, Geneva University Hospitals, Geneva, Switzerland.
Assunta CarusoDivision of Rheumatology, Department of Medicine, Geneva University Hospitals, Geneva, Switzerland.
Emiliana RodriguezDivision of Rheumatology, Department of Medicine, Geneva University Hospitals, Geneva, Switzerland.
Cem GabayDivision of Rheumatology, Department of Medicine, Geneva University Hospitals, Geneva, Switzerland.
University Hospital of Geneva · CHUniversity of Geneva · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Interleukin-18 is a proinflammatory cytokine, the activity of which is regulated by its natural inhibitor, IL-18 binding protein (IL-18BP). Elevated circulating levels of IL-18 have been observed in patients with systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still's disease (AOSD), two conditions associated with dysregulated innate immune responses. This study examines the expression and function of IL-18 and IL-18BP in K/BxN serum transfer arthritis (STA), a model that is uniquely dependent on innate immune responses. Methods: Naïve and serum transfer-induced arthritis (STA) wild-type (WT) mice were used to examine the articular levels of IL-18 and IL-18BP mRNA by RT-qPCR. The cellular sources of IL-18BP in the joints were determined by using Results: IL-18 and IL-18BP mRNA levels were significantly increased in arthritic as compared to normal joints. Synovial neutrophils, macrophages, and endothelial cells represented the cellular sources of IL-18BP in arthritic joints, whereas IL-18BP production was limited to endothelial cells in non-inflamed joints. The incidence and severity of arthritis were similar in IL-18BP KO and IL-18 KO compared to their WT littermates. Transcript levels of different inflammatory cytokines were not different in the two KO mouse lines compared to WT mice. Conclusion: Although IL-18 and IL-18BP levels were increased in arthritic joints, our results show that the IL-18/IL-18BP balance is not involved in the regulation of STA.

Indexed as

Interleukin-18Still's Disease, Adult-OnsetAnimalsCytokinesEndothelial CellsIntercellular Signaling Peptides and ProteinsMiceRNA, MessengerCytokinesIntercellular Signaling Peptides and ProteinsInterleukin-18interleukin-18 binding proteinRNA, Messengerinterleukin-18interleukin-18 binding proteinK/BxN serum transfer-induced arthritisrheumatoid arthritisStill’s diseasesystemic juvenile idiopathic arthritis

Identifiers

PMID37415987
PMCPMC10320286
OpenAlexW4381661267

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.