Evidence map›Paper›PMID 37415908›Full record

ArticleFrontiers in physiology2023

The eNAMPT/TLR4 inflammatory cascade drives the severity of intra-amniotic inflammation in pregnancy and predicts infant outcomes.

Mohamed Ahmed, Nancy G Casanova, Nahla Zaghloul, Akash Gupta, Marisela Rodriguez, Ian R Robbins, Carrie L Kempf, Xiaoguang Sun, Jin H Song, Vivian Reyes Hernon and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Mohamed AhmedDepartments of Pediatrics, University of Arizona Health Sciences, Tucson, AZ, United States.
Nancy G CasanovaDepartment of Medicine, University of Arizona Health Sciences, Tucson, AZ, United States.
Nahla ZaghloulDepartments of Pediatrics, University of Arizona Health Sciences, Tucson, AZ, United States.
Akash GuptaDepartments of Pediatrics, University of Arizona Health Sciences, Tucson, AZ, United States.
Marisela RodriguezDepartments of Pediatrics, University of Arizona Health Sciences, Tucson, AZ, United States.
Ian R RobbinsDepartments of Pediatrics, University of Arizona Health Sciences, Tucson, AZ, United States.
Carrie L KempfDepartment of Medicine, University of Arizona Health Sciences, Tucson, AZ, United States.
Xiaoguang SunDepartment of Medicine, University of Arizona Health Sciences, Tucson, AZ, United States.
Jin H SongDepartment of Medicine, University of Arizona Health Sciences, Tucson, AZ, United States.
Vivian Reyes HernonDepartment of Medicine, University of Arizona Health Sciences, Tucson, AZ, United States.
Saad SammaniDepartment of Medicine, University of Arizona Health Sciences, Tucson, AZ, United States.
Sara M CampDepartment of Medicine, University of Arizona Health Sciences, Tucson, AZ, United States.
Alvaro MoreiraDepartment of Pediatrics, UT Health San Antonio, Long School of Medicine, San Antonio, TX, United States.
Chaur-Dong HsuDepartment of Obstetrics and Gynecology, University of Arizona Health Sciences, Tucson, AZ, United States.
Joe G N GarciaDepartment of Medicine, University of Arizona Health Sciences, Tucson, AZ, United States.
University of Arizona · US

Funding

Structure-Function Analysis of nmMLCK in EC Barrier ResponsesP01HL126609 · NHLBI · UNIVERSITY OF FLORIDA · PI Saad Sammani · 2016 to 2026
$24.4M
Novel Involvement of NAMPT and TLR4 in PAH Vascular RemodelingR01HL141387 · NHLBI · UNIVERSITY OF FLORIDA · PI Joe G. N. Garcia, Ayako Makino · 2019 to 2026
$3.8M
Preclinical Development of a Novel eNAMPT-Neutralizing mAb for Pulmonary HypertensionR42HL164300 · NHLBI · AQUALUNG THERAPEUTICS CORP. · PI GARCIA, JOE G. N. · 2022 to 2024
$1.9M
Novel mechanism for eNAMPT secretion in PAH vascular remodelingF31AG082409 · NIA · UNIVERSITY OF FLORIDA · PI RODRIGUEZ, MARISELA · 2023 to 2024
$82k
NHLBI NIH HHS P01 HL126609NHLBI NIH HHS R01 HL141387NHLBI NIH HHS R42 HL164300NIA NIH HHS F31 AG082409
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

bronchopulmonary dysplasia (BPD)damage-associated molecular pattern protein (DAMP)eNAMPTintra-amniotic inflammation (IAI)mAbpreterm birth

Identifiers

PMID37415908
PMCPMC10319582
OpenAlexW4381429253

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.