ArticleFrontiers in microbiology2023
Metagenomics reveals novel microbial signatures of farm exposures in house dust.
Article in Frontiers in microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Indoor Microbiome: Sampling, Analysis and Emerging Trends.Environmental microbiology reports · 2026Pooled it
- Exploratory analysis of livestock waste treatment impacts on microbial diversity and antimicrobial resistance gene abundance.Microbiology spectrum · 2026Article
- Household environmental characteristics influence the house dust metagenome.Environmental research · 2026Article
- Linking the bed dust microbiome with environmental factors and child respiratory health.Annals of human biology · 2025Article
- Animal farming and the oral microbiome in the Agricultural Health Study.Environmental research · 2025Article
- Article
- Occupational farm work activities influence workers' indoor home microbiome.Environmental research · 2024Article
- Biocontrol in built environments to reduce pathogen exposure and infection risk.The ISME journal · 2024Review
- Association of milk microbiome with bovine mastitis before and after antibiotic therapy.Veterinary world · 2023Article
- Effects of microbes in pig farms on occupational exposed persons and the environment.AMB Express · 2023Article
- The Microbiome: From the Beginning to the End.Missouri medicineArticle
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11 authors.
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Abstract
Indoor home dust microbial communities, important contributors to human health, are shaped by environmental factors, including farm-related exposures. Advanced metagenomic whole genome shotgun sequencing (WGS) improves detection and characterization of microbiota in the indoor built-environment dust microbiome, compared to conventional 16S rRNA amplicon sequencing (16S). We hypothesized that the improved characterization of indoor dust microbial communities by WGS will enhance detection of exposure-outcome associations. The objective of this study was to identify novel associations of environmental exposures with the dust microbiome from the homes of 781 farmers and farm spouses enrolled in the Agricultural Lung Health Study. We examined various farm-related exposures, including living on a farm, crop versus animal production, and type of animal production, as well as non-farm exposures, including home cleanliness and indoor pets. We assessed the association of the exposures on within-sample alpha diversity and between-sample beta diversity, and the differential abundance of specific microbes by exposure. Results were compared to previous findings using 16S. We found most farm exposures were significantly positively associated with both alpha and beta diversity. Many microbes exhibited differential abundance related to farm exposures, mainly in the phyla
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