Evidence map›Paper›PMID 37415788›Full record

ArticleFrontiers in bioengineering and biotechnology2023

The response of human macrophages to 3D printed titanium antibacterial implants does not affect the osteogenic differentiation of hMSCs.

Amaia Garmendia Urdalleta, Mathijs Van Poll, Niamh Fahy, Janneke Witte-Bouma, Willem Van Wamel, Iulian Apachitei, Amir A Zadpoor, Lidy E Fratila-Apachitei, Eric Farrell

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Amaia Garmendia UrdalletaDepartment of Biomechanical Engineering, Faculty of Mechanical, Maritime and Materials Engineering, TU Delft, Delft, Netherlands.
Mathijs Van PollDepartment of Biomechanical Engineering, Faculty of Mechanical, Maritime and Materials Engineering, TU Delft, Delft, Netherlands.
Niamh FahyDepartment of Oral and Maxillofacial Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
Janneke Witte-BoumaDepartment of Oral and Maxillofacial Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
Willem Van WamelDepartment of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
Iulian ApachiteiDepartment of Biomechanical Engineering, Faculty of Mechanical, Maritime and Materials Engineering, TU Delft, Delft, Netherlands.
Amir A ZadpoorDepartment of Biomechanical Engineering, Faculty of Mechanical, Maritime and Materials Engineering, TU Delft, Delft, Netherlands.
Lidy E Fratila-ApachiteiDepartment of Biomechanical Engineering, Faculty of Mechanical, Maritime and Materials Engineering, TU Delft, Delft, Netherlands.
Eric FarrellDepartment of Oral and Maxillofacial Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
Erasmus MC · NLDelft University of Technology · NLShannon Applied Biotechnology Centre · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macrophage responses following the implantation of orthopaedic implants are essential for successful implant integration in the body, partly through intimate crosstalk with human marrow stromal cells (hMSCs) in the process of new bone formation. Additive manufacturing (AM) and plasma electrolytic oxidation (PEO) in the presence of silver nanoparticles (AgNPs) are promising techniques to achieve multifunctional titanium implants. Their osteoimmunomodulatory properties are, however, not yet fully investigated. Here, we studied the effects of implants with AgNPs on human macrophages and the crosstalk between hMSCs and human macrophages when co-cultured

Indexed as

human macrophageshuman marrow stromal cellsosteoimmunomodulationsilver nanoparticlestitanium bone implants

Identifiers

PMID37415788
PMCPMC10319998
OpenAlexW4381661568

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.