Evidence map›Paper›PMID 37415735›Full record

ArticleOncology research2023

The SMAD2/miR-4256/HDAC5/p16

Min Wang, Hailiang Zhao, Weiwei Chen, Caiqun Bie, Jinying Yang, Wenrui Cai, Chutian Wu, Yanfang Chen, Shufen Feng, Ying Shi and 7 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Implication of protein post translational modifications in gastric cancer.Frontiers in cell and developmental biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Min WangDepartment of Gastroenterology, The First Affiliated Hospital, Jinan University, Guangzhou, 510632, China.
Hailiang ZhaoDepartment of Gastroenterology, The First Affiliated Hospital, Jinan University, Guangzhou, 510632, China.
Weiwei ChenDepartment of Gastroenterology, The First People's Hospital of Zunyi, The Third Affiliated Hospital of Zunyi Medical University, Zunyi, 563099, China.
Caiqun BieDepartment of Gastroenterology, Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen, 518104, China.
Jinying YangDepartment of Gastroenterology, The First Affiliated Hospital, Jinan University, Guangzhou, 510632, China.
Wenrui CaiDepartment of Gastroenterology, The First Affiliated Hospital, Jinan University, Guangzhou, 510632, China.
Chutian WuDepartment of Gastroenterology, The First Affiliated Hospital, Jinan University, Guangzhou, 510632, China.
Yanfang ChenDepartment of Gastroenterology, The First Affiliated Hospital, Jinan University, Guangzhou, 510632, China.
Shufen FengDepartment of Gastroenterology, The First Affiliated Hospital, Jinan University, Guangzhou, 510632, China.
Ying ShiDepartment of Gastroenterology, The First Affiliated Hospital, Jinan University, Guangzhou, 510632, China.
Yuting LiDepartment of Gastroenterology, The First Affiliated Hospital, Jinan University, Guangzhou, 510632, China.
Huijun TangDepartment of Gastroenterology, Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen, 518104, China.
Lixian ZhongDepartment of Gastroenterology, The First Affiliated Hospital, Jinan University, Guangzhou, 510632, China.
Liliangzi GuoDepartment of Gastroenterology, The First Affiliated Hospital, Jinan University, Guangzhou, 510632, China.
Sisi ChenDepartment of Gastroenterology, The First Affiliated Hospital, Jinan University, Guangzhou, 510632, China.
Linjing LongDepartment of Gastroenterology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510799, China.
Shaohui TangDepartment of Gastroenterology, The First Affiliated Hospital, Jinan University, Guangzhou, 510632, China.
First Affiliated Hospital of Jinan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The dysregulation of exosomal microRNAs (miRNAs) plays a crucial role in the development and progression of cancer. This study investigated the role of a newly identified serum exosomal miRNA miR-4256 in gastric cancer (GC) and the underlying mechanisms. The differentially expressed miRNAs were firstly identified in serum exosomes of GC patients and healthy individuals using next-generation sequencing and bioinformatics. Next, the expression of serum exosomal miR-4256 was analyzed in GC cells and GC tissues, and the role of miR-4256 in GC was investigated by

Indexed as

MicroRNAsStomach NeoplasmsCell Line, TumorCell ProliferationCyclin-Dependent Kinase Inhibitor p16Gene Expression Regulation, NeoplasticHistone DeacetylasesHumansSignal TransductionSmad2 ProteinCyclin-Dependent Kinase Inhibitor p16HDAC5 protein, humanHistone DeacetylasesMicroRNAsSmad2 ProteinSMAD2 protein, humanGastric cancerHDAC5miR-4256p16INK4aSMAD2

Identifiers

PMID37415735
PMCPMC10319587
OpenAlexW4381956043

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.