ArticleArchives of physiotherapy2023
Cracking the code: unveiling the specific and shared mechanisms behind musculoskeletal interventions.
Article in Archives of physiotherapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Exercise Therapy Versus Manual Therapy for the Management of Pain Intensity, Disability, and Physical Function in People With Chronic Low Back Pain: A Systematic Review With Meta-Analysis and Meta-Regression.European journal of pain (London, England) · 2025Pooled it
- Guideline
- Specific and shared mechanisms mediating pain intensity and functional outcomes in chronic neck pain.Pain management · 2026Trial
- Loneliness, Self-Efficacy and Adaptive Coping: Mixed Methods Analysis of Mediation in a Peer Support Intervention for Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2025Trial
- Comparative Effects of Therapeutic Exercise and Manual Therapy Techniques on Self-Reported Disability in Chronic Non-Specific Low Back Pain: A Network Meta-Analysis.Journal of clinical medicine · 2026Review
- Considerations for Issues of Regression to the Mean and Contextual Effects in Clinical Trials for Pain in Rheumatic Diseases.Arthritis care & research · 2026Review
- Evaluating Manual Therapy in Musculoskeletal Pain: Why Certain Trial Designs May Overestimate Effectiveness-A Scoping Review.European journal of pain (London, England) · 2025Article
- Categorizing Treatment Mechanisms for Complementary and Integrative Musculoskeletal Interventions.International journal of osteopathic medicine : IJOM · 2025Article
- The mechanisms of manual therapy: A living review of systematic, narrative, and scoping reviews.PloS one · 2025Article
- A critical review of the role of manual therapy in the treatment of individuals with low back pain.The Journal of manual & manipulative therapy · 2024Review
- "Trying to explain the unexplainable": why research on contextual factors in musculoskeletal pain is needed.Pain management · 2024Article
- Manual therapy and exercise effects on inflammatory cytokines: a narrative overview.Frontiers in rehabilitation sciences · 2024Review
- The Role of Back Muscle Dysfunctions in Chronic Low Back Pain: State-of-the-Art and Clinical Implications.Journal of clinical medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMechanisms reflect the steps or processes through which an intervention unfolds and produces change in a specified outcome variable. Mechanisms are responsible for determining "how treatments work" which has emerged as a critical question for both developing theory and enhancing treatment efficacy. Studies that evaluate "how" treatments work, not just "if" treatments work are of considerable importance. DISCUSSION: Specific and shared mechanisms research is a promising approach which aims to improve patient outcomes by tailoring treatments to the specific needs of each patient. Mechanisms research is an underexplored area of research requiring a unique research design.
conclusionAlthough mechanisms research is still in its infancy, prioritizing the study of the mechanisms behind manual therapy interventions can provide valuable insight into optimizing patient outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.