ArticleCritical care (London, England)2023
Trauma-induced disturbances in ionized calcium levels correlate parabolically with coagulopathy, transfusion, and mortality: a multicentre cohort analysis from the TraumaRegister DGU
Article in Critical care (London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Prevalence and outcomes of hypocalcemia on ED arrival in traumatic patients before blood transfusions: a systematic review and meta-analysis.Scandinavian journal of trauma, resuscitation and emergency medicine · 2025Pooled it
- Hypocalcaemia upon arrival (HUA) in trauma patients who did and did not receive prehospital blood products: a systematic review and meta-analysis.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Pooled it
- The incidence of admission ionised hypocalcaemia in paediatric major trauma-A systematic review and meta-analysis.PloS one · 2024Pooled it
- Admission ionised calcium disturbances and adverse outcomes in paediatric major trauma: a UK multicentre retrospective cohort study.BMJ open · 2026Article
- Development and Validation of a Simplified Five-Variable Score for Predicting Massive Transfusion in Blunt-Trauma-Predominant Patients.Journal of clinical medicine · 2026Article
- Early calcium replacement after minimal blood transfusion is associated with adverse outcomes.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Prognostic Performance of the Lactate-to-Ionized Calcium Ratio for In-Hospital Mortality in Adult Major Trauma: A Retrospective Emergency Department Cohort Study.Diagnostics (Basel, Switzerland) · 2026Article
- Association Between Preoperative Calcium Levels and the Occurrence of Postoperative PE in Trauma Patients: A Retrospective Multicenter Cohort Study.World journal of surgery · 2026Article
- Survey of practices around the measurement and replacement of calcium in paediatric major trauma.BMJ paediatrics open · 2026Article
- Early transfusion strategies in haemorrhagic shock.Scandinavian journal of trauma, resuscitation and emergency medicine · 2026Article
- Just the facts: calcium administration in trauma patients receiving massive blood transfusions.CJEM · 2026Article
- Pre-Hospital Calcium Administration Reduces Incidence of Hypocalcemia and Mortality in Trauma Patients.Open access emergency medicine : OAEM · 2026Article
- Initial management of haemorrhagic war casualties: tactical priorities and innovative approaches in modern and future warfare.Critical care (London, England) · 2025Review
- Pre-hospital blood product transfusion and calcium management in the United Kingdom: a multicentre service evaluation.Scandinavian journal of trauma, resuscitation and emergency medicine · 2025Article
- Correlates of incident hypocalcemia amongst trauma patients in the Western Cape of South Africa: a secondary analysis of the Epidemiology and Outcomes of Prolonged Trauma Care (EpiC) study.Scandinavian journal of trauma, resuscitation and emergency medicine · 2025Article
- Hypocalcemia associated with adverse outcomes following severe traumatic injury in the Western Cape of South Africa: a secondary analysis of multicenter data from the Epidemiology and Outcomes of Prolonged Trauma Care (EpiC) study.International journal of emergency medicine · 2025Article
- Article
- Prehospital measurement and treatment of ionised hypocalcaemia by UK helicopter emergency medical services in trauma patients: a survey of current practice.Scandinavian journal of trauma, resuscitation and emergency medicine · 2025Article
- Interpretable machine learning model for early prediction of disseminated intravascular coagulation in critically ill children.Scientific reports · 2025Article
- Comparison of the lethal triad and the lethal diamond in severe trauma patients: a multicenter cohort.World journal of emergency surgery : WJES · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo which extent trauma- induced disturbances in ionized calcium (iCa2+) levels have a linear relationship with adverse outcomes remains controversial. The goal of this study was to determine the association between the distribution and accompanying characteristics of transfusion-independent iCa2+ levels versus outcome in a large cohort of major trauma patients upon arrival at the emergency department.
methodsA retrospective observational analysis of the TraumaRegister DGU
resultsIn the TraumaRegister DGU
conclusionsTransfusion-independent iCa2+ levels in major trauma patients upon arrival at the emergency department have a parabolic relationship with coagulopathy, need for transfusion, and mortality. Further research is needed to confirm whether iCa2+ levels change dynamically and are more a reflection of severity of injury and accompanying physiological derangements, rather than an individual parameter that needs to be corrected as such.
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