ArticleMolecular psychiatry2023
Neural mechanisms of emotional health in traumatic brain injury patients undergoing rTMS treatment.
Article in Molecular psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Theta Burst Stimulation Protocols for Schizophrenia: A Systematic Review and Network Meta-Analysis.JAMA network open · 2024Pooled it
- Early efficacy of rTMS intervention at week 2 predicts subsequent responses at week 24 in schizophrenia in a randomized controlled trial.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Trial
- Effect of rTMS on cerebral functional hierarchical structure in schizophrenia.Psychoradiology · 2026Article
- Effective Connectivity Alterations of Directed Brain Network in Pediatric Patients With Spinal Cord Injury.CNS neuroscience & therapeutics · 2025Article
- Trialing addiction neurocircuitry targets and directionality of brain stimulation effects: A deep TMS/fMRI trial in people with alcohol use disorder.Contemporary clinical trials communications · 2025Article
- Spectral imprint of structural embedding in effective connectivity.bioRxiv : the preprint server for biology · 2025Article
- Accelerated intermittent theta burst stimulation for pharmacological treatment-resistant bipolar depression: Protocol for double-blind, randomized, sham-controlled trial.PCN reports : psychiatry and clinical neurosciences · 2025Article
- Adaptive trial for the treatment of depressive symptoms associated with concussion using accelerated intermittent theta burst stimulation (ADEPT): rationale, design and methods.Frontiers in neurology · 2025Article
- Associations of serum neurofilament and asthma: evidence from the NHANES 2013-2014.Frontiers in neurology · 2025Article
- Clinical Insights Into Default Mode Network Abnormalities in Mild Traumatic Brain Injury: Unraveling Axonal Injury Through Functional, Structural, and Molecular Analyses.CNS neuroscience & therapeutics · 2024Article
- Article
- Traumatic Brain Injury and Neuromodulation Techniques in Rehabilitation: A Scoping Review.Biomedicines · 2024Article
- ENIGMA's simple seven: Recommendations to enhance the reproducibility of resting-state fMRI in traumatic brain injury.NeuroImage. Clinical · 2024Review
- Association of executive function with suicidality based on resting-state functional connectivity in young adults with subthreshold depression.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 5 countries.
Funding
Abstract
Emotional dysregulation such as that seen in depression, are a long-term consequence of mild traumatic brain injury (TBI), that can be improved by using neuromodulation treatments such as repetitive transcranial magnetic stimulation (rTMS). Previous studies provide insights into the changes in functional connectivity related to general emotional health after the application of rTMS procedures in patients with TBI. However, these studies provide little understanding of the underlying neuronal mechanisms that drive the improvement of the emotional health in these patients. The current study focuses on inferring the effective (causal) connectivity changes and their association with emotional health, after rTMS treatment of cognitive problems in TBI patients (N = 32). Specifically, we used resting state functional magnetic resonance imaging (fMRI) together with spectral dynamic causal model (spDCM) to investigate changes in brain effective connectivity, before and after the application of high frequency (10 Hz) rTMS over left dorsolateral prefrontal cortex. We investigated the effective connectivity of the cortico-limbic network comprised of 11 regions of interest (ROIs) which are part of the default mode, salience, and executive control networks, known to be implicated in emotional processing. The results indicate that overall, among extrinsic connections, the strength of excitatory connections decreased while that of inhibitory connections increased after the neuromodulation. The cardinal region in the analysis was dorsal anterior cingulate cortex (dACC) which is considered to be the most influenced during emotional health disorders. Our findings implicate the altered connectivity of dACC with left anterior insula and medial prefrontal cortex, after the application of rTMS, as a potential neural mechanism underlying improvement of emotional health. Our investigation highlights the importance of these brain regions as treatment targets in emotional processing in TBI.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.