ArticleMolecular psychiatry2023
Age-related vulnerability of the human brain connectome.
Article in Molecular psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Leukocyte Telomere Length and Cross-Sectional and Longitudinal Variations in Gray Matter Volume and Cortical Thickness.Brain and behavior · 2026Article
- Brain maintenance biomarkers from structural and functional interactions in aging and neurodegeneration.Nature communications · 2026Article
- Neural embedding of frailty in cognitively unimpaired aging and dementia across Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Spatially convergent functional MRI signatures of diabetes and male sex identify genetic vulnerabilities to accelerated brain ageing.Brain communications · 2026Article
- Creative experiences and brain clocks.Nature communications · 2025Article
- Cerebellar large-scale network connectivity in Parkinson's disease: associations with emotion, cognition, and aging effects.Brain imaging and behavior · 2025Article
- Aging diminishes interlaminar functional connectivity in the mouse cortical V1 and CA1 hippocampal regions.bioRxiv : the preprint server for biology · 2025Article
- Krakencoder: a unified brain connectome translation and fusion tool.Nature methods · 2025Article
- Are older adults more deceived by false advertising? Evidence from intra- and inter-brain connectivity in the prefrontal cortex during face-to-face deceptive sales.Social cognitive and affective neuroscience · 2025Article
- Age and Alzheimer's disease affect functional connectivity along separate axes of functional brain organization.bioRxiv : the preprint server for biology · 2025Article
- Distinct brain age gradients across the adult lifespan reflect diverse neurobiological hierarchies.Communications biology · 2025Article
- Fronto-occipital dyscommunication associates with brain hierarchy in schizophrenia.Communications biology · 2025Article
- Influence of individual's age on the characteristics of brain effective connectivity.GeroScience · 2025Article
- Age and gender-related patterns of arterial transit time and cerebral blood flow in healthy adults.NeuroImage · 2025Article
- The pathobiology of neurovascular aging.Neuron · 2025Review
- Stepwise connectivity of the entorhinal cortex along connectomic gradients in Alzheimer's disease.Brain communications · 2025Article
- Brain network fingerprints of Alzheimer's disease risk factors in mouse models with humanized APOE alleles.Magnetic resonance imaging · 2024Article
- APOE, Immune Factors, Sex, and Diet Interact to Shape Brain Networks in Mouse Models of Aging.bioRxiv : the preprint server for biology · 2024Article
- Age-related differences in structural and resting-state functional brain network organization across the adult lifespan: A cross-sectional study.Aging brain · 2024Article
- Atypical Hierarchical Connectivity Revealed by Stepwise Functional Connectivity in Aging.Bioengineering (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Multifactorial models integrating brain variables at multiple scales are warranted to investigate aging and its relationship with neurodegeneration. Our aim was to evaluate how aging affects functional connectivity of pivotal regions of the human brain connectome (i.e., hubs), which represent potential vulnerability 'stations' to aging, and whether such effects influence the functional and structural changes of the whole brain. We combined the information of the functional connectome vulnerability, studied through an innovative graph-analysis approach (stepwise functional connectivity), with brain cortical thinning in aging. Using data from 128 cognitively normal participants (aged 20-85 years), we firstly investigated the topological functional network organization in the optimal healthy condition (i.e., young adults) and observed that fronto-temporo-parietal hubs showed a highly direct functional connectivity with themselves and among each other, while occipital hubs showed a direct functional connectivity within occipital regions and sensorimotor areas. Subsequently, we modeled cortical thickness changes over lifespan, revealing that fronto-temporo-parietal hubs were among the brain regions that changed the most, whereas occipital hubs showed a quite spared cortical thickness across ages. Finally, we found that cortical regions highly functionally linked to the fronto-temporo-parietal hubs in healthy adults were characterized by the greatest cortical thinning along the lifespan, demonstrating that the topology and geometry of hub functional connectome govern the region-specific structural alterations of the brain regions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.