ArticleNature immunology2023
Transitional dendritic cells are distinct from conventional DC2 precursors and mediate proinflammatory antiviral responses.
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Article in Nature immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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60citing papers in PubMed
12.8field-weighted citation impact, top 1% of its field
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Who cites it
60 citing papers in PubMed, 78 citations in OpenAlex.
- Peri-weaning, diet-induced activation of an IFNγ-mediated regulatory circuit promotes cDC1 maturation and CD8Nature communications · 2026Article
- Distinct thymic pDC populations promote tumor immune tolerance through complementary mechanisms.Science advances · 2026Article
- Post-vaccination expansion of extrafollicular Th10 and regulatory Tfr cells distinguishes strong from weak influenza vaccine responses in older adults.medRxiv : the preprint server for health sciences · 2026Article
- Histone methyltransferase DOT1L differentially affects the development of dendritic cell subsets.Life science alliance · 2026Article
- Pan-cancer single-cell atlases of mouse and human tumor-associated dendritic cells.Nature communications · 2026Article
- Age- and tissue-dependent diversity of human plasmacytoid dendritic cells uncovers a cycling subset dominant in early life and cancer.Immunity · 2026Article
- TopBP1 orchestrates PU.1-IRF8 transcriptional programming of dendritic cell differentiation and Flt3L-driven tumor immunity.Experimental & molecular medicine · 2026Article
- Article
- Cohesin-mediated chromatin organization controls the differentiation and function of dendritic cells.Science immunology · 2026Article
- TSLP promotes GATA3-expressing effector regulatory T cells via DC2 derived from transitional DCs.Nature immunology · 2026Article
- A tolerogenic role for transitional dendritic cells in inflammation and cancer.Nature immunology · 2026Article
- Immune dysregulation triggered by inflammatory cytokines in patients with severe respiratory infections.Respiratory research · 2026Article
- Thymic myeloid cells are heterogenous and include a novel population of transitional dendritic cells.The Journal of experimental medicine · 2026Article
- The plasmacytoid dendritic cell paradox in cancer: impaired type I interferon responses in a nucleic acid-rich tumor microenvironment.Frontiers in immunology · 2026Review
- The normal human lymph node cell classification and landscape defined by high-dimensional spatial proteomics.PloS one · 2026Article
- Plasmacytoid dendritic cells in systemic and cutaneous lupus erythematosus: an evolving understanding.Frontiers in immunology · 2026Review
- Dendritic-cell diversity in equine blood revealed by single-cell transcriptomics.Discovery immunology · 2026Article
- Dendritic cells: the central partner for cancer immunity.Oncoimmunology · 2025Review
- The emerging role of dendritic cells in the tumor microenvironment: from antigen presentation to targeted immunotherapy.Cell death & disease · 2025Review
- Ontogenetic Diversification of Type 2 Conventional Dendritic Cells in the Bone Marrow: A Central Logic for Peripheral Immunity.Immunological reviews · 2025Review
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Authors and funding
18 authors at 3 institutions in 1 country.
Fernando Bandeira Sulczewski *Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
Raul A Maqueda-Alfaro *Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-3538-1176
Marcela Alcántara-Hernández *Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
Oriana A PerezDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Sanjana SaravananDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-5974-7710
Tae Jin YunDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
David SeongDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
Rebeca Arroyo HorneroDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-7026-7358
Hayley M Raquer-McKayDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-7404-8221
Eduardo EstevaDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Zachary R LanzarDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
Rebecca A LeylekDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
Nicholas M AdamsDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0001-5751-0480
Annesa DasDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Adeeb H RahmanMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Andres Gottfried-BlackmoreDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
Boris ReizisDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA. Boris.Reizis@nyulangone.org.ORCID http://orcid.org/0000-0003-1140-7853
Juliana IdoyagaDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA. jidoyaga@stanford.edu.ORCID http://orcid.org/0000-0002-4430-8862
Stanford University · USNew York University · USIcahn School of Medicine at Mount Sinai · US
Funding
Viral Assays CoreU19AI128949 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Donna L. Farber, Peter Alan Sims · 2017 to 2026
$26.4MInstitutional Career Development Core (KL2)KL2TR003143 · NCATS · STANFORD UNIVERSITY · PI ASCH, STEVEN M. · 2019 to 2023
$8.7MMolecular Control of Plasmacytoid Dendritic Cell Development and FunctionR37AI072571 · NIAID · UNIVERSITY OF CHICAGO · PI Boris Reizis · 2018 to 2026
$5.3MMolecular Control of Plasmacytoid Dendritic Cell Development and FunctionR01AI072571 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI REIZIS, BORIS · 2008 to 2017
$4.1MTransitional dendritic cells: identifying the origin and role of a novel innate immune population during viral infectionR01AI158808 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Juliana Idoyaga · 2021 to 2026
$3.5MCyTOFS10OD016318 · OD · STANFORD UNIVERSITY · PI NOLAN, GARRY P · 2013 to 2013
$600kNovel genetic tools for the analysis of plasmacytoid dendritic cell function in vivoR21AI147501 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI REIZIS, BORIS · 2019 to 2020
$466kNovel transcription factors modulating the development and function of pDCs and pDC-related cellsR21AI163775 · NIAID · STANFORD UNIVERSITY · PI IDOYAGA, JULIANA · 2021 to 2022
$437kDynamic Spatiotemporal Analysis of Immune Cells in the Tumor MicroenvironmentF32CA232666 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PEREZ, ORIANA · 2018 to 2020
$150kNCATS NIH HHS KL2 TR003143NCATS NIH HHS KL2TR003143NCI NIH HHS CA232666NCI NIH HHS F32 CA232666NIAID NIH HHS AI072571NIAID NIH HHS AI128949NIAID NIH HHS AI147501NIAID NIH HHS AI158808NIAID NIH HHS AI163775NIAID NIH HHS R01 AI072571NIAID NIH HHS R01 AI158808NIAID NIH HHS R21 AI147501NIAID NIH HHS R21 AI163775NIAID NIH HHS R37 AI072571NIAID NIH HHS U19 AI128949NIH HHS S10 OD016318
Abstract
High-dimensional approaches have revealed heterogeneity amongst dendritic cells (DCs), including a population of transitional DCs (tDCs) in mice and humans. However, the origin and relationship of tDCs to other DC subsets has been unclear. Here we show that tDCs are distinct from other well-characterized DCs and conventional DC precursors (pre-cDCs). We demonstrate that tDCs originate from bone marrow progenitors shared with plasmacytoid DCs (pDCs). In the periphery, tDCs contribute to the pool of ESAM
Indexed as
Bone MarrowDendritic CellsAnimalsAntiviral AgentsCell Adhesion MoleculesCell DifferentiationMiceAntiviral AgentsCell Adhesion MoleculesEsam protein, mouse
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