ArticleNature medicine2023
A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease.
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Article in Nature medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 193 papers, 6 of them syntheses that pooled it.
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193citing papers in PubMed, 6 pooled it
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Who cites it
193 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- A multiancestry polygenic risk score improves stratification in patients with hypertrophic cardiomyopathy.Nature cardiovascular research · 2026Pooled it
- Development and validation of a multiancestry and multitrait polygenic risk score for lung cancer.Nature communications · 2026Pooled it
- KidneyGenAfrica multi-cohort Genome-wide association study and polygenic prediction of kidney function in 110,000 Africans.Nature communications · 2026Pooled it
- Genome-wide analysis of heart failure yields insights into disease heterogeneity and enables prognostic prediction in the Japanese population.Nature communications · 2025Pooled it
- A systematic review of GWAS on CMR imaging traits: genetic insights into cardiovascular structure, function, and diseases.EBioMedicine · 2025Pooled it
- Pharmacogenomic scores in psychiatry: systematic review of current evidence.Translational psychiatry · 2024Pooled it
- Polygenic Risk Based Detection and Treatment of Subclinical Coronary Atherosclerosis in the PROACT Clinical Trials.Journal of the American College of Cardiology · 2026Trial
- Polygenic risk, aspirin, and primary prevention of coronary artery disease.European heart journal. Cardiovascular pharmacotherapy · 2025Trial
- Genomic Medicine Sweden: Advancing precision medicine at the national level.Journal of internal medicine · 2026Review
- All of Us diversity and scale yield context-dependent improvements in polygenic prediction.Nature genetics · 2026Article
- Rationale and design of Dongzong CArdIovascuLar Bio-imaging RegistrY (DAILY) study: Bridging multiomics, imaging and cardiovascular disease.American journal of preventive cardiology · 2026Article
- Use of a polygenic risk score to enhance early detection of coronary atherosclerosis.American journal of preventive cardiology · 2026Article
- Genetic and clinical risk factors for recurrent events among patients with coronary artery disease.American journal of preventive cardiology · 2026Article
- Artificial intelligence in biomarker discovery for diseases: diagnostic and therapeutic prospects.Signal transduction and targeted therapy · 2026Review
- Development and Validation of a Clinical Polygenic Risk Report in U.S.-Based Health Systems for 8 Cardiovascular Conditions.Journal of the American College of Cardiology · 2026Article
- Beyond LDL-C: Modern Lipid Management for ASCVD Prevention in Primary Care.Cardiology and therapy · 2026Review
- Multimodal deep learning enhances genomic risk prediction for cardiometabolic diseases.Briefings in bioinformatics · 2026Article
- Distinguishing different psychiatric disorders using DDx-PRS.Nature genetics · 2026Article
- Genetic evidence supports the combined targeting of lipoprotein(a) and LDL cholesterol to reduce coronary artery disease risk.Nature cardiovascular research · 2026Article
- Evaluating the Role ofDiagnostics (Basel, Switzerland) · 2026Article
133 more citing papers are in PubMed but not listed here.
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Authors and funding
21 authors.
Aniruddh P Patel *Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Minxian Wang *CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, China. wangmx@big.ac.cn.ORCID http://orcid.org/0000-0002-3753-508X
Yunfeng RuanCenter for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Satoshi KoyamaCenter for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Shoa L ClarkeStanford University School of Medicine, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0002-6592-1172
Xiong YangCAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, China.
Catherine TcheandjieuGladstone Institutes, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-9559-4339
Saaket AgrawalCenter for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Akl C FahedDivision of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Patrick T EllinorDivision of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2067-0533
Genes & Health Research Team; the Million Veteran Program
Philip S TsaoStanford University School of Medicine, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0001-7274-9318
Yan V SunVeteran Affairs Atlanta Healthcare System, Decatur, GA, USA.ORCID http://orcid.org/0000-0002-2838-1824
Kelly ChoVeteran Affairs Boston Healthcare System, Boston, MA, USA.
Peter W F WilsonVeteran Affairs Atlanta Healthcare System, Decatur, GA, USA.
Themistocles L AssimesStanford University School of Medicine, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0003-2349-0009
David A van HeelBlizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0002-0637-2265
Adam S ButterworthBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, and Centre of Research Excellence, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-6915-9015
Krishna G AragamDivision of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Pradeep NatarajanDivision of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8402-7435
Amit V KheraCenter for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. avkhera@mgh.harvard.edu.ORCID http://orcid.org/0000-0001-6535-5839
Funding
IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6MInstitutional Career Development Core (KL2)KL2TR003143 · NCATS · STANFORD UNIVERSITY · PI ASCH, STEVEN M. · 2019 to 2023
$8.7MClonal hematopoiesis in the Womens Health Initiative Memory StudyR01HL148565 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ALEXANDER P REINER, Eric A. Whitsel · 2019 to 2026
$5.9MClonal hematopoiesis in humans: determinants of development and progressionR01HL148050 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI BALLANTYNE, CHRISTIE MITCHELL, NATARAJAN, PRADEEP · 2019 to 2022
$5.9MEnabling improved applicability and transferability of polygenic scores across populationsU01HG011719 · NHGRI · MASSACHUSETTS GENERAL HOSPITAL · PI Alicia Martin · 2021 to 2026
$5.5MNew methods for constructing and evaluating polygenic scoresR01HG011432 · NHGRI · STANFORD UNIVERSITY · PI PRITCHARD, JONATHAN K · 2020 to 2023
$3.3MUsing Electrocardiogram Genetics to Inform Arrhythmia RiskR01HL157635 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ELLINOR, PATRICK THOMAS, MIRSHAHI, TOORAJ · 2022 to 2025
$2.9MPolygenic prediction of common, complex diseasesK08HG010155 · NHGRI · MASSACHUSETTS GENERAL HOSPITAL · PI KHERA, AMIT VIKRAM · 2018 to 2021
$1.1MPopulation Assessments of Aggregate Genetic Risk for DilatedýCardiomyopathyK08HL153937 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ARAGAM, KRISHNA G · 2021 to 2025
$846kIntegrating genomic and nongenomic risk for coronary artery diseaseK08HL161448 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Akl C Fahed · 2022 to 2026
$751kGenetics of Cardiometabolic Diseases in the VA PopulationI01BX003362 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI Kyong-Mi Chang, Philip S Tsao · 2017 to 2026
–Cardiovascular Disease Risk Factors, Cardiovascular Disease Risk Prediction, and Genetics in the Million Veteran ProgramI01BX004821 · VA · VETERANS HEALTH ADMINISTRATION · PI PETER WYMAN WILSON · 2020 to 2026
–BLRD VA I01 BX003362BLRD VA I01 BX004821British Heart Foundation CH/12/2/29428British Heart Foundation RG/18/13/33946Medical Research Council M009017Medical Research Council MR/X009777/1Medical Research Council MR/X009920/1NCATS NIH HHS KL2 TR003143NHGRI NIH HHS K08 HG010155NHGRI NIH HHS R01 HG011432NHGRI NIH HHS U01 HG011719NHLBI NIH HHS K08 HL153937NHLBI NIH HHS K08 HL161448NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL148050NHLBI NIH HHS R01 HL148565NHLBI NIH HHS R01 HL157635Wellcome Trust 210561/Z/18/ZWellcome Trust WT102627Wellcome Trust WT210561
Abstract
Identification of individuals at highest risk of coronary artery disease (CAD)-ideally before onset-remains an important public health need. Prior studies have developed genome-wide polygenic scores to enable risk stratification, reflecting the substantial inherited component to CAD risk. Here we develop a new and significantly improved polygenic score for CAD, termed GPS
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Coronary Artery DiseaseGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansPhenotypeRisk Factors
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