ArticleNature medicine2023
A prognostic risk score for development and spread of chronic pain.
Article in Nature medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
79 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prevalence of Depression and Anxiety Among Adults With Chronic Pain: A Systematic Review and Meta-Analysis.JAMA network open · 2025Pooled it
- Self-reported questionnaires assessing body perception disturbances in adults with chronic non-cancer pain: a scoping review.Frontiers in pain research (Lausanne, Switzerland) · 2025Pooled it
- Cost analysis comparing guideline-oriented biopsychosocial management to usual care for low-back pain: a cluster-randomized trial in occupational health primary care.Scandinavian journal of work, environment & health · 2025Trial
- Common Mechanisms in Migraine, Migraine-Related Neck Pain, and Low Back Pain: Implications for Treatment.Pain and therapy · 2026Review
- Body Posture-Related Differences in Pain Perception and Their Mediation by Cardiovascular Factors.Psychophysiology · 2026Article
- Unraveling the Genetic Basis of Self-Harm Phenotypes: New Perspectives on Its Links to Depression and Chronic Pain.Biological psychiatry global open science · 2026Article
- Dopamine transporter gene (Pain reports · 2026Article
- Understanding fibromyalgia beyond pain: emotional imbalance and the case for compassionate care.RMD open · 2026Review
- A predictive corticospinal model for pain perception.Cell reports. Medicine · 2026Article
- Association between low back movement control impairment test results and low back pain - Northern Finland birth cohort study 1966.BMC musculoskeletal disorders · 2026Article
- Navigating Health Care with Concurrent Jaw and Neck Pain: A Patient-Centered Perspective.JDR clinical and translational research · 2026Article
- Pain in People Living With Obesity: Baseline Multidimensional Profiles, Prevalence and Biopsychosocial Factors From a Cohort Study.European journal of pain (London, England) · 2026Article
- Why pain biomarkers cannot replace the patient experience.Nature neuroscience · 2026Article
- Multimorbidity in Chronic Overlapping Pain Conditions: From Burden to Integrated Care.Journal of clinical medicine · 2026Review
- Tinnitus and tinnitus disorder: Genetic, neurobiological, and clinical differentiation.iScience · 2026Review
- The role of biopsychosocial factors in classifying pain intensity across various chronic pain conditions.Scientific reports · 2026Article
- Temporomandibular Disorder-like Pain in Parkinson's Disease Is Associated with Motor Symptom Severity and Disability Levels.Journal of clinical medicine · 2026Article
- Review
- Does Combining the STarT Back Tool With a Polygenic Risk Score for Chronic Low Back Pain Improve Prediction of Work Disability Over 2 Years?European journal of pain (London, England) · 2026Article
- Perceived parenting styles and chronic pain course in mid-life in the general population.Pain reports · 2026Article
19 more citing papers are in PubMed but not listed here.
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18 authors.
Funding
Abstract
Chronic pain is a complex condition influenced by a combination of biological, psychological and social factors. Using data from the UK Biobank (n = 493,211), we showed that pain spreads from proximal to distal sites and developed a biopsychosocial model that predicted the number of coexisting pain sites. This data-driven model was used to identify a risk score that classified various chronic pain conditions (area under the curve (AUC) 0.70-0.88) and pain-related medical conditions (AUC 0.67-0.86). In longitudinal analyses, the risk score predicted the development of widespread chronic pain, the spreading of chronic pain across body sites and high-impact pain about 9 years later (AUC 0.68-0.78). Key risk factors included sleeplessness, feeling 'fed-up', tiredness, stressful life events and a body mass index >30. A simplified version of this score, named the risk of pain spreading, obtained similar predictive performance based on six simple questions with binarized answers. The risk of pain spreading was then validated in the Northern Finland Birth Cohort (n = 5,525) and the PREVENT-AD cohort (n = 178), obtaining comparable predictive performance. Our findings show that chronic pain conditions can be predicted from a common set of biopsychosocial factors, which can aid in tailoring research protocols, optimizing patient randomization in clinical trials and improving pain management.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.