ArticleNature chemistry2024
Kinetic control of shape deformations and membrane phase separation inside giant vesicles.
Article in Nature chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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Who cites it
29 citing papers in PubMed.
- Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Phase separation across membranes and condensates in cell organization and function.Nature reviews. Molecular cell biology · 2026Review
- Biomolecular Condensates as Protein Degradation Tools for Intracellular Targets.Nature communications · 2026Article
- Physiological implications of phase separation in vesicle organization and trafficking.BMC biology · 2026Review
- Selective membrane wetting of phase-separated giant unilamellar vesicles by coacervate droplets.Nature communications · 2026Article
- Macromolecular Condensates as Tunable Scaffolds for Bio-Inspired Silica Hybrids.Angewandte Chemie (International ed. in English) · 2026Article
- Condensate-mediated shape transformations of cellular membranes by capillary forces.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Dynamic, Reconfigurable, and Hierarchical Biosynthetic Composites via Collagen Self-Assembly within Highly Crowded Microgel Pastes.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Assembling Lipid Membrane Scaffolds on Microgel-Based Artificial Cells through Vesicle Fusion onto the Hydrogel Network.ACS nano · 2026Article
- Insights into de-mixing and morphology modulation in coacervate-membrane interactions from integrating experiments and simulations.Communications chemistry · 2025Article
- Combining Nanoscale Curvature and Polymer Osmotic Pressure for Efficient Giant Vesicle Assembly Under Physiological Conditions.Small methods · 2025Article
- Enzymatically reconfigurable liquid crystalline coacervate microdroplets as protocell models.Nature communications · 2025Article
- Molecular motor-driven reversible liquid-liquid phase separation of supramolecular assemblies.Nature communications · 2025Article
- Polymer-Wrapped Oil Droplets and Polymer Particles with Complex Curvilinear Polyhedral Geometries by Surfactant-Driven Elastocapillary Buckling of Polymer Capsules.Chemistry of materials : a publication of the American Chemical Society · 2025Article
- Transmembrane coupling drives the growth of liquid-like protein condensates.Biophysical journal · 2025Article
- Engineering Liquid Hierarchical Materials with DNA-Programmed Spherical Nucleic Acids.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Condensate-membrane interactions shape membranes, tune cytoskeletal assembly, and localize mRNAs.Current opinion in cell biology · 2025Review
- Designing Tunable DNA Condensates to Control Membrane Budding Transformation in Synthetic Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Article
- Adaptations of Bacterial Extracellular Vesicles in Response to Antibiotic Pressure.International journal of molecular sciences · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
A variety of cellular processes use liquid-liquid phase separation (LLPS) to create functional levels of organization, but the kinetic pathways by which it proceeds remain incompletely understood. Here in real time, we monitor the dynamics of LLPS of mixtures of segregatively phase-separating polymers inside all-synthetic, giant unilamellar vesicles. After dynamically triggering phase separation, we find that the ensuing relaxation-en route to the new equilibrium-is non-trivially modulated by a dynamic interplay between the coarsening of the evolving droplet phase and the interactive membrane boundary. The membrane boundary is preferentially wetted by one of the incipient phases, dynamically arresting the progression of coarsening and deforming the membrane. When the vesicles are composed of phase-separating mixtures of common lipids, LLPS within the vesicular interior becomes coupled to the membrane's compositional degrees of freedom, producing microphase-separated membrane textures. This coupling of bulk and surface phase-separation processes suggests a physical principle by which LLPS inside living cells might be dynamically regulated and communicated to the cellular boundaries.
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Registered trials
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