ArticleScientific reports2023
Association of constipation with increased risk of hypertension and cardiovascular events in elderly Australian patients.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Pooled it
- Association between constipation and risk of stroke: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Clinical Efficacy of Abdominal Massage Combined With Moxibustion for Treatment of Chronic Constipation in Elderly Patients.Neurogastroenterology and motility · 2026Trial
- Efficacy of honey suppositories in treating paediatric functional constipation: A comparative study.Journal of paediatrics and child health · 2025Trial
- Evaluating the Effect ofNutrients · 2024Trial
- Constipation prevalence and risk from prescribed medications in people with intellectual disability: Findings from an English mortality programme.Journal of intellectual disabilities : JOID · 2026Article
- Constipation: More Than a Quality-of-Life Issue.JACC. Asia · 2026Article
- Constipation and Incident Cardiovascular Disease: A Nationwide, Real-World Cohort Study.JACC. Asia · 2026Article
- Fecal microbiota transplantation for chronic constipation following bowel surgery in an elderly patient: A case report.Medicine · 2026Article
- Comparative Study of the Effectiveness of Cellulose, Pectin and Citrus Peel Powder in Alleviating Loperamide-Induced Constipation.Foods (Basel, Switzerland) · 2026Article
- Faecal metaproteomics analysis reveals a high cardiovascular risk profile across healthy individuals and heart failure patients.Gut microbes · 2025Article
- Triglycerides, Glucose Metabolism, and Type 2 Diabetes.International journal of molecular sciences · 2025Review
- Improving the nursing quality of non-pharmacological interventions for elderly patients with constipation in hospital: a best practice implementation project.JBI evidence implementation · 2025Article
- Masked hypertension in irritable bowel syndrome: A cause for concern?Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2025Article
- Article
- Gut-Heart Axis: The Role of Gut Microbiota and Metabolites in Heart Failure.Circulation research · 2025Review
- The inseparable relationship between constipation and blood pressure.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Neuroimmune Interactions and Their Role in Immune Cell Trafficking in Cardiovascular Diseases and Cancer.International journal of molecular sciences · 2025Review
- Association of anxiety status and anxiety duration with constipation in adult Americans: a cross-sectional study using data from the NHANES 2007-2010.BMC gastroenterology · 2025Article
- Association between constipation and risk of coronary heart disease: a systematic review and meta-analysis of cohort studies.Frontiers in cardiovascular medicine · 2025Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The association between constipation and cardiovascular risk is unclear. This population-level matched cohort study compared the association of constipation with hypertension and incident cardiovascular events in 541,172 hospitalized patients aged ≥ 60 years. For each constipation admission, one exact age-matched non-constipated admission was randomly selected from all hospitalizations within 2 weeks to form the comparison cohort. The association of constipation with hypertension and cardiovascular events (myocardial infarction, angina, stroke and transient ischemic attack) were analysed using a series of binary logistic regressions adjusting for age, sex, cardiovascular risk factors, gastrointestinal disorders and sociological factors. Patients with constipation had a higher multivariate-adjusted risk for hypertension (odds ratio [OR], 1.96; 95% confidence interval [CI] 1.94-1.99; P < 0.001). Compared to patients with neither constipation nor hypertension, there was a higher multivariate-adjusted risk for cardiovascular events in patients with constipation alone (OR, 1.58; 95% CI 1.55-1.61; P < 0.001) or hypertension alone (OR, 6.12; 95% CI 5.99-6.26; P < 0.001). In patients with both constipation and hypertension, the risk for all cardiovascular events appeared to be additive (OR, 6.53; 95% CI 6.40-6.66; P < 0.001). In conclusion, among hospital patients aged 60 years or older, constipation is linked to an increased risk of hypertension and cardiovascular events. These findings suggest that interventions to address constipation may reduce cardiovascular risk in elderly patients.
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