Evidence map›Paper›PMID 37414835›Full record

ArticleSpinal cord2023

Early and intensive motor training to enhance neurological recovery in people with spinal cord injury: trial protocol.

Lisa A Harvey, Joanne V Glinsky, Jackie Chu, Robert D Herbert, Hueiming Liu, Stephen Jan, Laurent Billot, Giorgio Scivoletto, Annemie I Spooren, Henk A Seelen and 26 more

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Spinal cord, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors.

Lisa A HarveyJohn Walsh Centre for Rehabilitation Research, University of Sydney, Kolling Institute, Sydney, NSW, Australia. l.harvey@usyd.edu.au.ORCID 0000-0002-4365-0236
Joanne V GlinskyJohn Walsh Centre for Rehabilitation Research, University of Sydney, Kolling Institute, Sydney, NSW, Australia.
Jackie ChuJohn Walsh Centre for Rehabilitation Research, University of Sydney, Kolling Institute, Sydney, NSW, Australia.ORCID 0000-0001-5810-2788
Robert D HerbertNeuroscience Research Australia (NeuRA), Sydney, NSW, Australia.
Hueiming LiuThe George Institute for Global Health, University of New South Wales, Sydney, NSW, Australia.ORCID 0000-0001-9077-8673
Stephen JanThe George Institute for Global Health, University of New South Wales, Sydney, NSW, Australia.
Laurent BillotThe George Institute for Global Health, University of New South Wales, Sydney, NSW, Australia.ORCID 0000-0002-4975-9793
Giorgio ScivolettoI.R.C.C.S. Santa Lucia Foundation, Rome, Italy.ORCID 0000-0001-5766-6952
Annemie I SpoorenREVAL, Hasselt University, Hasselt, Belgium.
Henk A SeelenAdelante Centre of Expertise in Rehabilitation and Audiology, Hoensbroek, The Netherlands.
Marsha BenJohn Walsh Centre for Rehabilitation Research, University of Sydney, Kolling Institute, Sydney, NSW, Australia.
Keira TranterJohn Walsh Centre for Rehabilitation Research, University of Sydney, Kolling Institute, Sydney, NSW, Australia.
Lydia W ChenRoyal North Shore Hospital, Sydney, NSW, Australia.
Donna RaineyRoyal Rehab, Sydney, NSW, Australia.
Christine RimmerFiona Stanley Hospital, Perth, WA, Australia.
Vivien JorgensenSunnaas Rehabilitation Hospital, Nesodden, Norway.ORCID 0000-0001-9437-7009
Fernanda Di NatalPrince of Wales Hospital, Sydney, NSW, Australia.
Sophie DenisPrince of Wales Hospital, Sydney, NSW, Australia.
Emilie J GollanThe Princess Alexandra Hospital, Brisbane, QLD, Australia.
Federica TamburellaI.R.C.C.S. Santa Lucia Foundation, Rome, Italy.ORCID 0000-0001-9920-1010
Jacqui AgostinelloThe Royal Talbot Rehabilitation Centre, Melbourne, VIC, Australia.
Charlotte M van Laake-GeelenAdelante Centre of Expertise in Rehabilitation and Audiology, Hoensbroek, The Netherlands.
Chris BellRepatriation General Hospital, Adelaide, SA, Australia.
Claire LincolnQueen Elizabeth National Spinal Injures Unit, Glasgow, UK.
Janneke M StolwijkCenter of Excellence for Rehabilitation Medicine, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands.ORCID 0000-0001-6793-691X
Jessica van der LedeCenter of Excellence for Rehabilitation Medicine, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands.
Sue PaddisonLondon Spinal Cord Injury Centre, Royal National Orthopaedic Hospital Trust, Middlesex, UK.
Kristine OostraGhent University Hospital, Ghent, Belgium.
Ian D CameronJohn Walsh Centre for Rehabilitation Research, University of Sydney, Kolling Institute, Sydney, NSW, Australia.
Gerard WeberRoyal Rehab, Sydney, NSW, Australia.
Catherine SherringtonSydney School of Public Health, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
Andrew K NunnVictorian Spinal Cord Service, Austin Health, Melbourne, VIC, Australia.
Emma-Leigh SynnottFiona Stanley Hospital, Perth, WA, Australia.
Euan McCaugheyQueen Elizabeth National Spinal Injures Unit, Glasgow, UK.ORCID 0000-0001-6596-110X
Jasbeer KaurRoyal North Shore Hospital, Sydney, NSW, Australia.
Sachin ShettyPrince of Wales Hospital, Sydney, NSW, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

designProtocol for a multi-centre randomised controlled trial (the SCI-MT trial).

objectivesTo determine whether 10 weeks of intensive motor training enhances neurological recovery in people with recent spinal cord injury (SCI).

settingFifteen spinal injury units in Australia, Scotland, England, Italy, Netherlands, Norway, and Belgium.

methodsA pragmatic randomised controlled trial will be undertaken. Two hundred and twenty people with recent SCI (onset in the preceding 10 weeks, American Spinal Injuries Association Impairment Scale (AIS) A lesion with motor function more than three levels below the motor level on one or both sides, or an AIS C or D lesion) will be randomised to receive either usual care plus intensive motor training (12 h of motor training per week for 10 weeks) or usual care alone. The primary outcome is neurological recovery at 10 weeks, measured with the Total Motor Score from the International Standards for Neurological Classification of SCI. Secondary outcomes include global measures of motor function, ability to walk, quality of life, participants' perceptions about ability to perform self-selected goals, length of hospital stay and participants' impressions of therapeutic benefit at 10 weeks and 6 months. A cost-effectiveness study and process evaluation will be run alongside the trial. The first participant was randomised in June 2021 and the trial is due for completion in 2025.

conclusionsThe findings of the SCI-MT Trial will guide recommendations about the type and dose of inpatient therapy that optimises neurological recovery in people with SCI.

trial registrationACTRN12621000091808 (1.2.2021).

Indexed as

Spinal Cord InjuriesHumansMulticenter Studies as TopicPragmatic Clinical Trials as TopicQuality of LifeRandomized Controlled Trials as TopicRecovery of FunctionTreatment OutcomeWalking

Identifiers

PMID37414835
PMCPMC10495259

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.