Evidence map›Paper›PMID 37414463›Full record

ArticleRNA (New York, N.Y.)2023

Identification of RNA-binding proteins' direct effects on gene expression via the degradation tag system.

Kailey Worner, Qiuying Liu, Katharine R Maschhoff, Wenqian Hu

Open access · bronzeAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kailey WornerDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA.
Qiuying LiuDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA.
Katharine R MaschhoffDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA.
Wenqian HuDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA hu.wenqian@mayo.edu.ORCID 0000-0003-3577-3604
Mayo Clinic · US

Funding

Molecular mechanistic studies of long “noncoding” RNAs in mammalian cell differentiationR01GM136869 · NIGMS · MAYO CLINIC ROCHESTER · PI HU, WENQIAN · 2021 to 2024
$1.4M
NIGMS NIH HHS R01 GM136869
6 · The paper itself

Abstract

RNA-binding proteins (RBPs) are critical regulators of gene expression. An RBP typically binds to multiple mRNAs and modulates their expression. Although loss-of-function experiments on an RBP can infer how it regulates a specific target mRNA, the results are confounded by potential secondary effects due to the attenuation of all other interactions of the target RBP. For example, regarding the interaction between Trim71, an evolutionarily conserved RBP, and

Indexed as

Protein BiosynthesisRNA-Binding ProteinsRNA, MessengerRNA-Binding ProteinsRNA, MessengerAgo2direct effectdTAGRNA-binding protein

Identifiers

PMID37414463
PMCPMC10578468
OpenAlexW4383377954

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.