Evidence map›Paper›PMID 37414411›Full record

ArticleEuropean heart journal2023

Diet, cardiovascular disease, and mortality in 80 countries.

Andrew Mente, Mahshid Dehghan, Sumathy Rangarajan, Martin O'Donnell, Weihong Hu, Gilles Dagenais, Andreas Wielgosz, Scott A Lear, Li Wei, Rafael Diaz and 25 more

Open access · bronzeAbstract read
In one paragraph

Article in European heart journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 5 pooled it
40.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 5 syntheses or guidelines pooled it, 138 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Guideline
  5. Pooled it
  6. Trial
  7. Article
  8. Time-Varying Impact of Steatosis and Alcohol on Mortality: A Marginal Structural Model of the Canadian Longitudinal Study on Aging.Liver international : official journal of the International Association for the Study of the Liver · 2026
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  19. Associations and interaction effects of socioeconomic, lifestyle, and genetic factors on intrinsic capacity.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
    Article
  20. Article

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

35 authors at 20 institutions in 19 countries.

Andrew MentePopulation Health Research Institute, Hamilton Health Sciences and McMaster University, 2nd Floor, Room C2-105, 237 Barton St East, Hamilton, Ontario L8L 2X2, Canada.ORCID 0000-0001-6879-7675
Mahshid DehghanPopulation Health Research Institute, Hamilton Health Sciences and McMaster University, 2nd Floor, Room C2-105, 237 Barton St East, Hamilton, Ontario L8L 2X2, Canada.ORCID 0000-0003-2636-4518
Sumathy RangarajanPopulation Health Research Institute, Hamilton Health Sciences and McMaster University, 2nd Floor, Room C2-105, 237 Barton St East, Hamilton, Ontario L8L 2X2, Canada.ORCID 0000-0003-2420-5986
Martin O'DonnellDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Weihong HuPopulation Health Research Institute, Hamilton Health Sciences and McMaster University, 2nd Floor, Room C2-105, 237 Barton St East, Hamilton, Ontario L8L 2X2, Canada.
Gilles DagenaisDepartment of Medicine, Université Laval Institut universitaire de cardiologie et de pneumologie de Québec, Quebec City G1V 4G5, Canada.
Andreas WielgoszDepartment of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Scott A LearFaculty of Health Sciences, and Department of Biomedical Physiology & Kinesiology, Simon Fraser University Vancouver, Burnaby, British Columbia, Canada.
Li WeiState Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, Xicheng District, China.
Rafael DiazEstudios Clinicos Latinoamerica ECLA, Universidad Nacional de Rosario, Rosario, Santa Fe, Argentina.
Alvaro AvezumInternational Research Center, Hospital Alemão Oswaldo Cruz & UNISA, Sao Paulo, São Paulo estado, SP Brazil.ORCID 0000-0002-3073-6890
Patricio Lopez-JaramilloMasira Research Institute, Medical School, Universidad de Santander (UDES), Bucaramanga, Santander, Colombia.ORCID 0000-0002-9122-8742
Fernando LanasFrancisco Salazar, Universidad de La Frontera, Temuco, Araucanía, Chile.ORCID 0000-0003-3595-9759
Sumathi SwaminathanDivision of Nutrition, St John's Research Institute, Koramangala, Bangalore, Karnataka, India.
Manmeet KaurPostgraduate Institute of Medical Education and Research, School of Public Health, Chandigarh, Punjab and Haryana, India.
K VijayakumarHealth Action by People, Amrita Institute of Medical Sciences, Trivandrum, Kerala, India.
Viswanathan MohanDirector and Chief of Diabetes Research, Madras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Centre, Chennai, Tamil Nadu, India.ORCID 0000-0001-5038-6210
Rajeev GuptaEternal Heart Care Centre and Research Institute, Rajasthan University of Health Sciences, Jaipur, Rajasthan, India.ORCID 0000-0002-8356-3137
Andrzej SzubaDepartment of Internal Medicine, Wroclaw Medical University, 4th Military Hospital, Wroclaw, Lower Silesian Voivodeship, Poland.
Romaina IqbalDepartment of Community Health Sciences and Medicine, Aga Khan University, Karachi, Sindh, Pakistan.
Rita YusufDepartment of Life Sciences, Independent University, Bangladesh, Bashundhara, Dhaka, Dhaka District, Bangladesh.
Noushin MohammadifardIsfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Isfahan Province, Iran.
Rasha KhatibDepartments of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Nafiza Mat NasirDepartment of Primary Care Medicine, Faculty of Medicine, Universiti Teknologi MARA (UiTM), Shah Alam, Selangor, Malaysia.
Kubilay KarsidagDepartment of Internal Medicine, Division of Endocrinology, Medical Faculty of Istanbul University, Istanbul, Istanbul Province, Turkey.
Annika RosengrenDepartment of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg and Sahlgrenska University Hospital/Östra Hospital, Gothenburg, Västergötland, Sweden.
Afzalhussein YusufaliHatta Hospital, Dubai Health Authority, Dubai Medical University, Dubai, United Arab Emirates.ORCID 0000-0003-3378-2646
Edelweiss Wentzel-ViljoenFaculty of Health Sciences, Centre of Excellence for Nutrition, Potchefstroom, North West Province, South Africa.
Jephat ChifambaCollege of Health Sciences, Physiology Department, University of Zimbabwe, Harare, Harare Metropolitan Province, Zimbabwe.
Antonio DansDepartment of Medicine, University of the Philippines, Ermita, Manila, Metro Manila, Philippines.
Khalid F AlhabibDepartment of Cardiac Sciences, King Fahad Cardiac Center, College of Medicine, King Saud University, Riyadh, Riyadh Province, Saudi Arabia.ORCID 0000-0002-6692-3874
Karen YeatesDepartment of Medicine, Queen's University, 94 Stuart Street, Etherington Hall, Kingston, Ontario, Canada.
Koon TeoPopulation Health Research Institute, Hamilton Health Sciences and McMaster University, 2nd Floor, Room C2-105, 237 Barton St East, Hamilton, Ontario L8L 2X2, Canada.
Hertzel C GersteinPopulation Health Research Institute, Hamilton Health Sciences and McMaster University, 2nd Floor, Room C2-105, 237 Barton St East, Hamilton, Ontario L8L 2X2, Canada.ORCID 0000-0001-8072-2836
Salim YusufPopulation Health Research Institute, Hamilton Health Sciences and McMaster University, 2nd Floor, Room C2-105, 237 Barton St East, Hamilton, Ontario L8L 2X2, Canada.
Population Health Research Institute · CAAga Khan University · PKChinese Academy of Medical Sciences & Peking Union Medical College · CNDubai Health Authority · AEHealth Action by People · INHospital Alemão Oswaldo Cruz · BRIndependent University · BDInstitut universitaire de cardiologie et de pneumologie de Québec · CAIsfahan University of Medical Sciences · IRIstanbul University · TRKing Saud University · SAMadras Diabetes Research Foundation · INMcMaster University · CANational University of Rosario · ARNorthwestern University · USNorth-West University · ZAPost Graduate Institute of Medical Education and Research · INQueen's University · CARajasthan University of Health Sciences · INSahlgrenska University Hospital · SE

Funding

Medical Research Council
6 · The paper itself

Abstract

aimsTo develop a healthy diet score that is associated with health outcomes and is globally applicable using data from the Prospective Urban Rural Epidemiology (PURE) study and replicate it in five independent studies on a total of 245 000 people from 80 countries. METHODS AND

resultsA healthy diet score was developed in 147 642 people from the general population, from 21 countries in the PURE study, and the consistency of the associations of the score with events was examined in five large independent studies from 70 countries. The healthy diet score was developed based on six foods each of which has been associated with a significantly lower risk of mortality [i.e. fruit, vegetables, nuts, legumes, fish, and dairy (mainly whole-fat); range of scores, 0-6]. The main outcome measures were all-cause mortality and major cardiovascular events [cardiovascular disease (CVD)]. During a median follow-up of 9.3 years in PURE, compared with a diet score of ≤1 points, a diet score of ≥5 points was associated with a lower risk of mortality [hazard ratio (HR) 0.70; 95% confidence interval (CI) 0.63-0.77)], CVD (HR 0.82; 0.75-0.91), myocardial infarction (HR 0.86; 0.75-0.99), and stroke (HR 0.81; 0.71-0.93). In three independent studies in vascular patients, similar results were found, with a higher diet score being associated with lower mortality (HR 0.73; 0.66-0.81), CVD (HR 0.79; 0.72-0.87), myocardial infarction (HR 0.85; 0.71-0.99), and a non-statistically significant lower risk of stroke (HR 0.87; 0.73-1.03). Additionally, in two case-control studies, a higher diet score was associated with lower first myocardial infarction [odds ratio (OR) 0.72; 0.65-0.80] and stroke (OR 0.57; 0.50-0.65). A higher diet score was associated with a significantly lower risk of death or CVD in regions with lower than with higher gross national incomes (P for heterogeneity <0.0001). The PURE score showed slightly stronger associations with death or CVD than several other common diet scores (P < 0.001 for each comparison).

conclusionA diet comprised of higher amounts of fruit, vegetables, nuts, legumes, fish, and whole-fat dairy is associated with lower CVD and mortality in all world regions, especially in countries with lower income where consumption of these foods is low.

Indexed as

Cardiovascular DiseasesMyocardial InfarctionStrokeAnimalsDietHumansProspective StudiesRisk FactorsVegetablesCardiovascular eventsDietary patternsDiet qualityDiverse populationsGlobalMortality

Identifiers

PMID37414411
PMCPMC10361015
OpenAlexW4383315097

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.