Evidence map›Paper›PMID 37410951›Full record

ArticleNano letters2023

Enhancing Intracellular Optical Performance and Stability of Engineered Nanomaterials via Aqueous Two-Phase Purification.

Aceer Nadeem, Aidan Kindopp, Ian Wyllie, Lauren Hubert, James Joubert, Sophie Lucente, Ewelina Randall, Prakrit V Jena, Daniel Roxbury

Open access · greenAbstract read
In one paragraph

Article in Nano letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Near-Infrared Fluorescent Single-Walled Carbon Nanotubes for Biosensing.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Review
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Aceer NadeemDepartment of Chemical Engineering, University of Rhode Island, Kingston, Rhode Island 02881, United States.ORCID 0000-0002-5381-3561
Aidan KindoppDepartment of Chemical Engineering, University of Rhode Island, Kingston, Rhode Island 02881, United States.
Ian WyllieDepartment of Chemical Engineering, University of Rhode Island, Kingston, Rhode Island 02881, United States.
Lauren HubertDepartment of Chemical Engineering, University of Rhode Island, Kingston, Rhode Island 02881, United States.
James JoubertDepartment of Chemical Engineering, University of Rhode Island, Kingston, Rhode Island 02881, United States.
Sophie LucenteDepartment of Chemical Engineering, University of Rhode Island, Kingston, Rhode Island 02881, United States.
Ewelina RandallMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.
Prakrit V JenaMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.ORCID 0000-0001-5493-3058
Daniel RoxburyDepartment of Chemical Engineering, University of Rhode Island, Kingston, Rhode Island 02881, United States.ORCID 0000-0003-2812-3523
University of Rhode Island · USMemorial Sloan Kettering Cancer Center · US

Funding

Training CoreP20GM103430 · NIGMS · UNIVERSITY OF RHODE ISLAND · PI Bongsup P Cho · 2012 to 2026
$63.6M
NIGMS NIH HHS P20 GM103430
6 · The paper itself

Abstract

Supramolecular hybrids of DNA and single-walled carbon nanotubes (SWCNTs) have been introduced in numerous biosensing applications due to their unique optical properties. Recent aqueous two-phase (ATP) purification methods for SWCNTs have gained popularity by introducing specificity and homogeneity into the sensor design process. Using murine macrophages probed by near-infrared and Raman microscopies, we show that ATP purification increases the retention time of DNA-SWCNTs within cells while simultaneously enhancing the optical performance and stability of the engineered nanomaterial. Over a period of 6 h, we observe 45% brighter fluorescence intensity and no significant change in emission wavelength of ATP-purified DNA-SWCNTs relative to as-dispersed SWCNTs. These findings provide strong evidence of how cells differentially process engineered nanomaterials depending on their state of purification, lending to the future development of more robust and sensitive biosensors with desirable

Indexed as

NanostructuresNanotubes, CarbonAdenosine TriphosphateAnimalsDNAMiceSurface-Active AgentsWaterAdenosine TriphosphateDNANanotubes, CarbonSurface-Active AgentsWateraqueous two-phase purificationbiosensingnanoparticle exocytosisnanoparticle optical stabilitynear-infrared fluorescence

Identifiers

PMID37410951
PMCPMC11068083
OpenAlexW4383313153

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.