ArticleJournal of applied physiology (Bethesda, Md. : 1985)2023
The forearm vascular response to sympathetic activation is attenuated in female, but not male, participants following acute intermittent hypoxia.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 3 citations in OpenAlex.
- Sex-related differences in the peripheral vascular response to hypoxia: Implications in health and relevance for obstructive sleep apnoea.Experimental physiology · 2026Review
- Role of overweight and obesity on vascular responses to the cold pressor test and hypoxia in women.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Flow-mediated dilation decreases in women, but not men, following mild acute intermittent hypoxia.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Plethysmographic assessment of vasomotor response in patients with congestive heart failure before and after heart transplantation.Biomedical optics express · 2024Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Acute exposure to hypoxia promotes both an increase in sympathetic nervous system activity (SNA) and local vasodilation. In rodents, intermittent hypoxia (IH)-mediated increases in SNA are associated with an increase in blood pressure in males but not females; notably, the protective effect of female sex is lost following ovariectomy. These data suggest the vascular response to hypoxia and/or SNA following IH may be sex- and/or hormone specific-although mechanisms are unclear. We hypothesized that hypoxia-mediated vasodilation and SNA-mediated vasoconstriction would be unchanged following acute IH in male adults. We further hypothesized that hypoxic vasodilation would be augmented and SNA-mediated vasoconstriction would be attenuated in female adults following acute IH, with the greatest effect when endogenous estradiol was high. Twelve male (25 ± 1 yr) and 10 female (25 ± 1 yr) participants underwent 30 min of IH. Females were studied in a low (early follicular) and high (late follicular) estradiol state. Preceding and following IH, participants completed two trials [steady-state hypoxia and cold pressor test (CPT)], where forearm blood flow and blood pressure were measured and used to determine forearm vascular conductance (FVC). The FVC response to hypoxia (
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