ArticleArthritis & rheumatology (Hoboken, N.J.)2023
Relation of Intra-Articular Mineralization to Knee Pain in Knee Osteoarthritis: A Longitudinal Analysis in the MOST Study.
Article in Arthritis & rheumatology (Hoboken, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- The association between articular calcium crystal deposition and knee osteoarthritis, joint pain and inflammation: a cross-sectional study.Skeletal radiology · 2025Trial
- The association of CT-detected intra-articular calcification with MRI-detected effusion-synovitis and Hoffa-synovitis in knee OA: The Multicenter Osteoarthritis study.Osteoarthritis and cartilage · 2026Observational
- Review
- Human Knee as an Organ: Joint Tissue Collection, Processing, and Scoring for Multimodal Analyses.Laboratory investigation; a journal of technical methods and pathology · 2026Review
- Imaging and management of calcium pyrophosphate deposition disease.Skeletal radiology · 2025Review
- Ultrasonography in the assessment of calcium pyrophosphate deposition disease.Skeletal radiology · 2025Review
- Chondrocalcinosis and incident knee osteoarthritis: findings from 2 large prospective cohorts with 20 years of follow-up.Annals of the rheumatic diseases · 2025Observational
- Osteoarthritis as an evolutionary legacy: Biological ageing and chondrocyte hypertrophy.Osteoarthritis and cartilage open · 2025Review
- Is It Time to Revisit the Role of Interleukin-1 Inhibitors in Osteoarthritis?Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Review
- Application of the Oxford Arthroplasty Early Recovery Score for patients undergoing Joint arthroplasty.American journal of translational research · 2025Article
- Predictive Modeling of Osteoarthritis Using Biochemical Markers: A Cross-Sectional Analysis.Journal of orthopaedic case reports · 2024Article
- Intra-Articular Mineralization on Computerized Tomography of the Knee and Risk of Cartilage Damage: The Multicenter Osteoarthritis Study.Arthritis & rheumatology (Hoboken, N.J.) · 2024Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveIntra-articular (IA) calcium crystal deposition is common in knee osteoarthritis (OA), but of unclear significance. It is possible that low-grade, crystal-related inflammation may contribute to knee pain. We examined the longitudinal relation of computed tomography (CT)-detected IA mineralization to the development of knee pain.
methodsWe used data from the National Institutes of Health-funded longitudinal Multicenter Osteoarthritis Study. Participants had knee radiographs and bilateral knee CTs at baseline, and pain assessments every 8 months for 2 years. CT images were scored using the Boston University Calcium Knee Score. We longitudinally examined the relation of CT-detected IA mineralization to the risk of frequent knee pain (FKP), intermittent or constant knee pain worsening, and pain severity worsening using generalized linear mixed-effects models.
resultsWe included 2,093 participants (mean age 61 years, 57% women, mean body mass index 28.8 kg/m
conclusionCT-detected IA mineralization was associated with risk of having more frequent, persistent, and worsening knee pain over 2 years. Targeting IA mineralization may have therapeutic potential for pain improvement in knee OA.
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Registered trials
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