Evidence map›Paper›PMID 37410754›Full record

ArticleArthritis & rheumatology (Hoboken, N.J.)2023

IĸB Protein BCL3 as a Controller of Osteogenesis and Bone Health.

Hussain Jaffery, Carmen Huesa, Sabarinadh Chilaka, John Cole, James Doonan, Moeed Akbar, Lynette Dunning, Kathleen Elizabeth Tanner, Rob J van 't Hof, Iain B McInnes and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis & rheumatology (Hoboken, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Unveiling the multifaceted roles of BCL3: biological functions and disease implications.Apoptosis : an international journal on programmed cell death · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Hussain JafferySchool of Infection & Immunity, University of Glasgow, Glasgow, UK.ORCID 0000-0002-1408-3260
Carmen HuesaSchool of Infection & Immunity, University of Glasgow, Glasgow and Institute of Biomedical & Environmental Health, University of the West of Scotland, Paisley, UK.ORCID 0000-0002-4989-4258
Sabarinadh ChilakaSchool of Infection & Immunity, University of Glasgow, Glasgow, UK.
John ColeSchool of Infection & Immunity, University of Glasgow, Glasgow, UK.
James DoonanSchool of Infection & Immunity, University of Glasgow, Glasgow, UK.ORCID 0000-0001-6933-4840
Moeed AkbarSchool of Infection & Immunity, University of Glasgow, Glasgow, UK.ORCID 0000-0002-6923-4724
Lynette DunningInstitute of Biomedical & Environmental Health, University of the West of Scotland, Paisley, UK.
Kathleen Elizabeth TannerJames Watt School of Engineering, University of Glasgow, Glasgow, UK.ORCID 0000-0003-2257-0218
Rob J van 't HofInstitute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.ORCID 0000-0002-8193-6788
Iain B McInnesSchool of Infection & Immunity, University of Glasgow, Glasgow, UK.ORCID 0000-0003-4449-8501
Ruaidhrí J CarmodySchool of Infection & Immunity, University of Glasgow, Glasgow, UK.ORCID 0000-0002-9474-4507
Carl S GoodyearSchool of Infection & Immunity, University of Glasgow, Glasgow, UK.ORCID 0000-0001-5926-5941
University of Glasgow · GBQueen Mary University of London · GBUniversity of Liverpool · GBUniversity of the West of Scotland · GB

Funding

Versus Arthritis 22072Versus Arthritis 22858Wellcome TrustWellcome Trust 099786/Z/12/AWellcome Trust 099786/Z/12/Z
6 · The paper itself

Abstract

objectiveIĸB protein B cell lymphoma 3-encoded protein (BCL3) is a regulator of the NF-κB family of transcription factors. NF-κB signaling fundamentally influences the fate of bone-forming osteoblasts and bone-resorbing osteoclasts, but the role of BCL3 in bone biology has not been investigated. The objective of this study was to evaluate BCL3 in skeletal development, maintenance, and osteoarthritic pathology.

methodsTo assess the contribution of BCL3 to skeletal homeostasis, neonatal mice (n = 6-14) lacking BCL3 (Bcl3

resultsEvaluation of Bcl3

conclusionCumulatively, these findings demonstrate that BCL3 controls developmental mineralization to enable appropriate bone formation, whereas in a pathological setting, it contributes to skeletal pathology.

Indexed as

B-Cell Lymphoma 3 ProteinBone and BonesOsteogenesisAnimalsBone DensityCell DifferentiationMiceNF-kappa BOsteoblastsOsteoclastsB-Cell Lymphoma 3 ProteinBcl3 protein, mouseNF-kappa B

Identifiers

PMID37410754
PMCPMC10952620
OpenAlexW4383337701

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.