Evidence map›Paper›PMID 37410741›Full record

ArticlePloS one2023

Verbal autopsy analysis of childhood deaths in rural Gambia.

Baleng Mahama Wutor, Isaac Osei, Lobga Babila Galega, Esu Ezeani, Williams Adefila, Ilias Hossain, Golam Sarwar, Grant Mackenzie

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Article
  4. Article
  5. Article
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  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Baleng Mahama WutorMedical Research Council Unit The Gambia at London School of Hygiene & Tropical Medicine, Fajara, The Gambia.ORCID 0000-0001-7267-0570
Isaac OseiMedical Research Council Unit The Gambia at London School of Hygiene & Tropical Medicine, Fajara, The Gambia.
Lobga Babila GalegaMedical Research Council Unit The Gambia at London School of Hygiene & Tropical Medicine, Fajara, The Gambia.
Esu EzeaniMedical Research Council Unit The Gambia at London School of Hygiene & Tropical Medicine, Fajara, The Gambia.
Williams AdefilaMedical Research Council Unit The Gambia at London School of Hygiene & Tropical Medicine, Fajara, The Gambia.ORCID 0000-0002-1928-4862
Ilias HossainMedical Research Council Unit The Gambia at London School of Hygiene & Tropical Medicine, Fajara, The Gambia.
Golam SarwarMedical Research Council Unit The Gambia at London School of Hygiene & Tropical Medicine, Fajara, The Gambia.
Grant MackenzieMedical Research Council Unit The Gambia at London School of Hygiene & Tropical Medicine, Fajara, The Gambia.
MRC Unit the Gambia · GMLondon School of Hygiene & Tropical Medicine · GBThe University of Melbourne · AU

Funding

Medical Research Council MC_EX_MR/R006121/1Medical Research Council MC_UU_00031/8
6 · The paper itself

Abstract

backgroundIn low-resource settings, it is challenging to ascertain the burden and causes of under-5 mortality as many deaths occur outside health facilities. We aimed to determine the causes of childhood deaths in rural Gambia using verbal autopsies (VA). METHODOLOGY: We used WHO VA questionnaires to conduct VAs for deaths under-5 years of age in the Basse and Fuladu West Health and Demographic Surveillance Systems (HDSS) in rural Gambia between September 01, 2019, and December 31, 2021. Using a standardized cause of death list, two physicians assigned causes of death and discordant diagnoses were resolved by consensus.

resultsVAs were conducted for 89% (647/727) of deaths. Of these deaths, 49.5% (n = 319) occurred at home, 50.1% (n = 324) in females, and 32.3% (n = 209) in neonates. Acute respiratory infection including pneumonia (ARIP) (33.7%, n = 137) and diarrhoeal diseases (23.3%, n = 95) were the commonest primary causes of death in the post-neonatal period. In the neonatal period, unspecified perinatal causes of death (34.0%, n = 71) and deaths due to birth asphyxia (27.3%, n = 57) were the commonest causes of death. Severe malnutrition (28.6%, n = 185) was the commonest underlying cause of death. In the neonatal period, deaths due to birth asphyxia (p-value<0.001) and severe anaemia (p-value = 0.03) were more likely to occur at hospitals while unspecified perinatal deaths (p-value = 0.01) were more likely to occur at home. In the post-neonatal period, deaths due to ARIP (p-value = 0.04) and diarrhoeal disease (p-value = 0.001) were more likely to occur among children aged 1-11 months and 12-23 months respectively.

conclusionAccording to VA analysis of deaths identified within two HDSS in rural Gambia, half of deaths amongst children under-5 in rural Gambia occur at home. ARIP and diarrhoea, and the underlying cause of severe malnutrition remain the predominant causes of child mortality. Improved health care and health-seeking behaviour may reduce childhood deaths in rural Gambia.

Indexed as

Protein-Energy MalnutritionRespiratory Tract InfectionsAsphyxiaAutopsyCause of DeathChildDiarrheaFemaleGambiaHumansInfantInfant, NewbornPregnancy

Identifiers

PMID37410741
PMCPMC10325104
OpenAlexW4383337742

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.