Evidence map›Paper›PMID 37410448›Full record

ReviewPhysiological reviews2024

The conducted vasomotor response and the principles of electrical communication in resistance arteries.

Galina Yu Mironova, Paulina M Kowalewska, Mohammed El-Lakany, Cam Ha T Tran, Maria Sancho, Anil Zechariah, William F Jackson, Donald G Welsh

Abstract readReview
In one paragraph

Review in Physiological reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Erythrocytes as Active Regulators of Blood Flow: A Brief Overview.Advances in experimental medicine and biology · 2026
    Review
  4. Article
  5. Article
  6. The machinery of healthy vasoconstriction: an overview.Pflugers Archiv : European journal of physiology · 2025
    Review
  7. The machinery of healthy vasodilatation: an overview.Pflugers Archiv : European journal of physiology · 2025
    Review
  8. Article
  9. CaInflammation and regeneration · 2024
    Review
  10. Electro-metabolic signaling.The Journal of general physiology · 2024
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Galina Yu MironovaDepartment of Physiology and Pharmacology, Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.ORCID 0000-0002-3698-7682
Paulina M KowalewskaDepartment of Physiology and Pharmacology, Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.
Mohammed El-LakanyDepartment of Physiology and Pharmacology, Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.ORCID 0000-0002-9139-3158
Cam Ha T TranDepartment of Physiology, Faculty of Medicine, University of Nevada (Reno), Reno, Nevada, United States.
Maria SanchoDepartment of Physiology, Faculty of Medicine, Complutense University of Madrid, Madrid, Spain.ORCID 0000-0003-4750-1040
Anil ZechariahDivision of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland and Labrador, St. John's, Newfoundland, Canada.
William F JacksonDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan, United States.ORCID 0000-0002-9657-0141
Donald G WelshDepartment of Physiology and Pharmacology, Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.

Funding

The perivascular adipocyte: integrating mechanical and structural cues into vasoactive functionP01HL152951 · NHLBI · MICHIGAN STATE UNIVERSITY · PI Stephanie W Watts · 2022 to 2026
$13.3M
Cerebral parenchymal arteriole dysfunction and cognitive decline in a life-long high fat feeding modelR01HL137694 · NHLBI · MICHIGAN STATE UNIVERSITY · PI DORRANCE, ANNE M., JACKSON, WILLIAM F. · 2017 to 2020
$2.1M
NHLBI NIH HHS P01 HL152951NHLBI NIH HHS R01 HL137694
6 · The paper itself

Abstract

Biological tissues are fed by arterial networks whose task is to set blood flow delivery in accordance with energetic demand. Coordinating vasomotor activity among hundreds of neighboring segments is an essential process, one dependent upon electrical information spreading among smooth muscle and endothelial cells. The "conducted vasomotor response" is a functional expression of electrical spread, and it is this process that lies at the heart of this critical review. Written in a narrative format, this review first highlights historical manuscripts and then characterizes the conducted response across a range of preparations. Trends are highlighted and used to guide subsequent sections, focused on cellular foundations, biophysical underpinnings, and regulation in health and disease. Key information has been tabulated; figures reinforce grounding concepts and reveal a framework within which theoretical and experimental work can be rationalized. This summative review highlights that despite 30 years of concerted experimentation, key aspects of the conducted response remain ill defined. Of note is the need to rationalize the regulation and deterioration of conduction in pathobiological settings. New quantitative tools, along with transgenic technology, are discussed as a means of propelling this investigative field forward.

Indexed as

ArteriesVascular ResistanceVasomotor SystemAnimalsHumansMuscle, Smooth, Vasculararteriesblood flowendothelial cellsgap junctionsion channelssmooth muscle cells

Identifiers

PMID37410448
PMCPMC11918294

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.