Evidence map›Paper›PMID 37410385›Full record

ArticleInternational journal of epidemiology2023

Mediation and moderation of genetic risk of obesity through eating behaviours in two UK cohorts.

Shahina Begum, Eleanor C Hinton, Zoi Toumpakari, Timothy M Frayling, Laura Howe, Laura Johnson, Natalia Lawrence

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of epidemiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Shahina BegumDepartment of Psychology, College of Life and Environmental Sciences, University of Exeter, Exeter, UK.ORCID 0000-0002-3521-8865
Eleanor C HintonNIHR Bristol BRC Nutrition Theme, University Hospitals Bristol Education & Research Centre, University of Bristol, Bristol, UK.
Zoi ToumpakariCentre for Exercise, Nutrition and Health Sciences, School for Policy Studies, University of Bristol, Bristol, UK.
Timothy M FraylingGenetics of Complex Traits, University of Exeter Medical School, Exeter, UK.
Laura HowePopulation Health Sciences, Bristol Medical School/MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Laura JohnsonCentre for Exercise, Nutrition and Health Sciences, School for Policy Studies, University of Bristol, Bristol, UK.
Natalia LawrenceDepartment of Psychology, College of Life and Environmental Sciences, University of Exeter, Exeter, UK.
University of Bristol · GBUniversity of Exeter · GB

Funding

Medical Research Council MR/M020894/1Medical Research Council MR/N0137941/1Wellcome Trust
6 · The paper itself

Abstract

backgroundThe mechanisms underlying genetic predisposition to higher body mass index (BMI) remain unclear.

methodsWe hypothesized that the relationship between BMI-genetic risk score (BMI-GRS) and BMI was mediated via disinhibition, emotional eating and hunger, and moderated by flexible (but not rigid) restraint within two UK cohorts: the Genetics of Appetite Study (GATE) (n = 2101, 2010-16) and the Avon Longitudinal Study of Parents and Children (ALSPAC) (n = 1679, 2014-18). Eating behaviour was measured by the Adult Eating Behaviour Questionnaire and Three-Factor Eating Questionaire-51.

resultsThe association between BMI-GRS and BMI were partially mediated by habitual, emotional and situational disinhibition in the GATE/ALSPAC meta-mediation [standardized betaindirect 0.04, 95% confidence interval (CI) 0.02-0.06; 0.03, 0.01-0.04; 0.03, 0.01-0.04, respectively] external hunger and internal hunger in the GATE study (0.02, 0.01-0.03; 0.01, 0.001-0.02, respectively). There was evidence of mediation by emotional over/undereating and hunger in the ALSPAC study (0.02, 0.01-0.03; 0.01, 0.001-0.02; 0.01, 0.002-0.01, respectively). Rigid or flexible restraint did not moderate the direct association between BMI-GRS and BMI, but high flexible restraint moderated the effect of disinhibition subscales on BMI (reduction of the indirect mediation by -5% to -11% in GATE/ALSPAC) and external hunger (-5%) in GATE. High rigid restraint reduced the mediation via disinhibition subscales in GATE/ALSPAC (-4% to -11%) and external hunger (-3%) in GATE.

conclusionsGenetic predisposition to a higher BMI was partly explained by disinhibition and hunger in two large cohorts. Flexible/rigid restraint may play an important role in moderating the impact of predisposition to higher BMI.

Indexed as

Feeding BehaviorObesityAdultBody Mass IndexChildGenetic Predisposition to DiseaseHumansLongitudinal StudiesSurveys and QuestionnairesUnited KingdomALSPACappetiteBMIdietary restraintdisinhibitioneating behaviourgenesgenetic risk scorehungerObesity

Identifiers

PMID37410385
PMCPMC10749755
OpenAlexW4383302340

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.