Evidence map›Paper›PMID 37410303›Full record

ArticleInternational urology and nephrology2024

The influence of Klotho protein and prooxidant-antioxidant balance combination on the mortality of HD patients.

Tamara Milošević, Miron Sopić, Jelena Vekić, Azra Guzonjić, Sanja Vujčić, Snežana Pešić, Milica Miljković-Trailović, Radomir Naumović, Jelena Kotur-Stevuljević

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Article in International urology and nephrology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Tamara MiloševićLaboratory Diagnostics Service, Zvezdara Clinical Hospital Center, Belgrade, Serbia. tamaramedbio@gmail.com.ORCID http://orcid.org/0000-0003-1612-9450
Miron SopićFaculty of Pharmacy, Department for Medical Biochemistry, University of Belgrade, Belgrade, Serbia.
Jelena VekićFaculty of Pharmacy, Department for Medical Biochemistry, University of Belgrade, Belgrade, Serbia.
Azra GuzonjićFaculty of Pharmacy, Department for Medical Biochemistry, University of Belgrade, Belgrade, Serbia.
Sanja VujčićFaculty of Pharmacy, Department for Medical Biochemistry, University of Belgrade, Belgrade, Serbia.
Snežana PešićClinical Department of Nephrology and Metabolic Disorders With Dialysis "Prof. Dr. Vasilije Jovanovic", Zvezdara Clinical Hospital Center, Belgrade, Serbia.
Milica Miljković-TrailovićFaculty of Pharmacy, Department for Medical Biochemistry, University of Belgrade, Belgrade, Serbia.
Radomir NaumovićClinical Department of Nephrology and Metabolic Disorders With Dialysis "Prof. Dr. Vasilije Jovanovic", Zvezdara Clinical Hospital Center, Belgrade, Serbia.
Jelena Kotur-StevuljevićFaculty of Pharmacy, Department for Medical Biochemistry, University of Belgrade, Belgrade, Serbia.
University of Belgrade · RSKliničko Bolnički Centar Zvezdara · RS

Funding

Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja 451-03-47/2023-01/ 200161
6 · The paper itself

Abstract

purposeEnd-stage renal disease patients on chronic hemodialysis (HD) have a shortened life expectancy compared to the general population. The aim of this study was to evaluate a possible link between three new and emerging factors in renal pathophysiology: Klotho protein, telomere length in peripheral blood mononuclear cells (TL) and redox status parameters before HD (bHD) and after HD (aHD), and to test mortality prediction capability of these emerging parameters in a population of HD patients.

methodsThe study included 130 adult patients with average age 66 (54-72), on HD (3 times per week; 4-5 h per session). Klotho level, TL, routine laboratory parameters, dialysis adequacy and redox status parameters: advanced oxidation protein products (AOPP), prooxidant-antioxidant balance (PAB), superoxide anion (O

resultsKlotho concentration was significantly higher aHD; 68.2 (22.6-152.9) vs. bHD 64.2 (25.5-119.8) (p = 0.027). The observed increase in TL was not statistically significant. AOPP, PAB, SHG, and SOD activity were significantly increased aHD (p > 0.001). The patients with the highest mortality risk score (MRS) had significantly higher PAB bHD (p = 0.002). Significantly lower O

conclusionDecreased Klotho and TL attrition as well as redox status disturbance could be connected with higher mortality rate in HD patients.

Indexed as

AntioxidantsKidney Failure, ChronicAdultAdvanced Oxidation Protein ProductsAgedBiomarkersHumansLeukocytes, MononuclearOxidative StressReactive Oxygen SpeciesRenal DialysisSerum AlbuminSuperoxide DismutaseAdvanced Oxidation Protein ProductsAntioxidantsBiomarkersReactive Oxygen SpeciesSerum AlbuminSuperoxide DismutaseHemodialysisKlotho proteinOxidative stressTelomeres

Identifiers

PMID37410303
OpenAlexW4383302429

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.