Evidence map›Paper›PMID 37410223›Full record

ArticlePurinergic signalling2024

ADP as a novel stimulus for NLRP3-inflammasome activation in mice fails to translate to humans.

Julius Wissemann, Adrian Heidenreich, Helene Zimmermann, Juliane Engelmann, Jasper Jansen, Dymphie Suchanek, Dirk Westermann, Dennis Wolf, Peter Stachon, Julian Merz

Abstract read
In one paragraph

Article in Purinergic signalling, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Julius Wissemann *Cardiology and Angiology, Medical Center, University Heart Center Freiburg-Bad Krozingen, University of Freiburg, Freiburg, Germany.
Adrian Heidenreich *Cardiology and Angiology, Medical Center, University Heart Center Freiburg-Bad Krozingen, University of Freiburg, Freiburg, Germany.
Helene ZimmermannCardiology and Angiology, Medical Center, University Heart Center Freiburg-Bad Krozingen, University of Freiburg, Freiburg, Germany.
Juliane EngelmannCardiology and Angiology, Medical Center, University Heart Center Freiburg-Bad Krozingen, University of Freiburg, Freiburg, Germany.
Jasper JansenCardiology and Angiology, Medical Center, University Heart Center Freiburg-Bad Krozingen, University of Freiburg, Freiburg, Germany.
Dymphie SuchanekCardiology and Angiology, Medical Center, University Heart Center Freiburg-Bad Krozingen, University of Freiburg, Freiburg, Germany.
Dirk WestermannCardiology and Angiology, Medical Center, University Heart Center Freiburg-Bad Krozingen, University of Freiburg, Freiburg, Germany.
Dennis WolfCardiology and Angiology, Medical Center, University Heart Center Freiburg-Bad Krozingen, University of Freiburg, Freiburg, Germany.
Peter StachonCardiology and Angiology, Medical Center, University Heart Center Freiburg-Bad Krozingen, University of Freiburg, Freiburg, Germany.
Julian MerzCardiology and Angiology, Medical Center, University Heart Center Freiburg-Bad Krozingen, University of Freiburg, Freiburg, Germany. julian.merz@uniklinik-freiburg.de.

Funding

Deutsche Forschungsgemeinschaft 467077284
6 · The paper itself

Abstract

The NLRP3-inflammasome is a cytosolic multiprotein complex that triggers an inflammatory response to certain danger signals. Recently adenosine diphosphate (ADP) was found to activate the NLRP3-inflammasome in murine macrophages via the P2Y

Indexed as

Adenosine DiphosphateInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinAnimalsHumansMacrophagesMiceMice, Inbred C57BLMonocytesTHP-1 CellsAdenosine DiphosphateInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanNlrp3 protein, mouseAdenosine DiphosphateInflammationNLRP3P2Y1PBMCsPurinergic Receptor

Identifiers

PMID37410223
PMCPMC11189352

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.