Evidence map›Paper›PMID 37410152›Full record

ArticleClinical oral investigations2023

Backscatter from therapeutic doses of ionizing irradiation does not impair cell migration on titanium implants in vitro.

Lisa Printzell, Janne Elin Reseland, Nina Frederike Jeppesen Edin, Jan Eirik Ellingsen, Hanna Tiainen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical oral investigations, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Lisa PrintzellDepartment of Prosthodontics, Institute of Clinical Dentistry, Faculty for Dentistry, University of Oslo, PO box 1109, 0317, Blindern, Oslo, Norway. lisa.printzell@odont.uio.no.ORCID http://orcid.org/0000-0001-7134-1484
Janne Elin ReselandDepartment of Biomaterials, Institute of Clinical Dentistry, Faculty for Dentistry, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0001-5743-4297
Nina Frederike Jeppesen EdinDepartment of Physics, Faculty of Mathematics and Natural Science, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-6995-131X
Jan Eirik EllingsenDepartment of Prosthodontics, Institute of Clinical Dentistry, Faculty for Dentistry, University of Oslo, PO box 1109, 0317, Blindern, Oslo, Norway.ORCID http://orcid.org/0000-0001-9182-6251
Hanna TiainenDepartment of Biomaterials, Institute of Clinical Dentistry, Faculty for Dentistry, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0003-2757-6213
University of Oslo · NO

Funding

Dentsply Sirona I-AS-15-050Kreftforeningen 6902696
6 · The paper itself

Abstract

objectiveThe influence of radiation backscatter from titanium on DNA damage and migration capacity of human osteoblasts (OBs) and mesenchymal stem cells (MSCs) may be critical for the osseointegration of dental implants placed prior to radiotherapy. In order to evaluate effects of radiation backscatter, the immediate DNA damage and migration capacity of OBs and MSCs cultured on titanium or plastic were compared after exposure to ionizing irradiation. MATERIALS AND

methodsHuman OBs and MSCs were seeded on machined titanium, moderately rough fluoride-modified titanium, or tissue culture polystyrene, and irradiated with nominal doses of 2, 6, 10, or 14 Gy. Comet assay was performed immediately after irradiation, while a scratch wound healing assay was initiated 24 h post-irradiation. Fluorescent live cell imaging documented the migration.

resultsDNA damage increased with higher dose and with backscatter from titanium, and MSCs were significantly more affected than OBs. All doses of radiation accelerated the cell migration on plastic, while only the highest dose of 10 Gy inhibited the migration of both cell types on titanium.

conclusionsHigh doses (10 Gy) of radiation inhibited the migration capacity of both cell types on titanium, whereas lower doses (2 and 6 Gy) did not affect the migration of either OBs or MSCs. CLINICAL RELEVANCE: Fractionated doses of 2 Gy/day, as distributed in conventional radiotherapy, appear not to cause severe DNA damage or disturb the migration of OBs or MSCs during osseointegration of dental implants.

Indexed as

Dental ImplantsCell MovementHumansPlasticsRadiation, IonizingTitaniumDental ImplantsPlasticsTitaniumCell migrationDNA damageMesenchymal stem cellsOsteoblastsRadiation backscatterTitanium implants

Identifiers

PMID37410152
PMCPMC10492688
OpenAlexW4383301667

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.