ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2023
Variations in Genes Encoding Human Papillomavirus Binding Receptors and Susceptibility to Cervical Precancer.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05247853 (Long-Term Human Papillomavirus Vaccination Effectiveness and Immunity in Rwandan Women Living With and Without Human Immunodeficiency Virus), which is not on this map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Long-Term Human Papillomavirus Vaccination Effectiveness and Immunity in Rwandan Women Living With and Without Human Immunodeficiency Virus
TypeobservationalSponsorMontefiore Medical CenterRan2021 to 2024Enrolled3,127ConditionsCervical Cancer, Human Papilloma Virus, Human Immunodeficiency Virus, HPV-Related CarcinomaArmsBlood collection, Oral, cervicovaginal and anal specimen collection, Anoscopy & Biopsy of Acetowhite Lesions, Colposcopy & Biopsy of Acetowhite Lesions, Ablative Treatment
3 · Its place in the literature
Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
15 authors at 12 institutions in 1 country.
Amrita MukherjeeDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama.ORCID 0000-0003-1713-2926
Yuanfan YeDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama.ORCID 0000-0002-8545-9819
Howard W WienerDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama.ORCID 0009-0009-7071-5531
Mark H KuniholmDepartment of Epidemiology & Biostatistics, University at Albany, State University of New York, Rensselaer, New York.ORCID 0000-0002-0173-9806
Howard MinkoffDepartment of Obstetrics & Gynecology, Maimonides Medical Center, Brooklyn, New York.ORCID 0000-0002-7800-7195
Kate MichelDepartment of Medicine, Georgetown University Medical Center, Washington, DC.ORCID 0000-0002-1852-9450
Joel PalefskyDepartment of Medicine, University of California, San Francisco, California.ORCID 0000-0002-5097-3818
Gypsyamber D'SouzaDepartment of Epidemiology, Johns Hopkins University, Baltimore, Maryland.ORCID 0000-0002-0575-7948
Lisa RahangdaleDepartment of Obstetrics & Gynecology, University of North Carolina School of Medicine, Chapel Hill, North Carolina.ORCID 0000-0002-4444-7969
Kenneth R ButlerDivision of Geriatric Medicine/Gerontology, University of Mississippi Medical Center, Jackson, Mississippi.ORCID 0000-0003-3198-8835
Mirjam-Colette KempfDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama.ORCID 0000-0003-3796-4906
Staci L SudengaDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.ORCID 0000-0001-7305-8738
Bradley E AouizeratTranslational Research Center, College of Dentistry, New York University, New York, New York.ORCID 0000-0002-6047-9397
Akinyemi I OjesinaDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama.ORCID 0000-0003-0755-3639
Sadeep ShresthaDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama.ORCID 0000-0002-7002-357X
University of Alabama at Birmingham · USAlbany State University · USGeorgetown University · USJohns Hopkins University · USKaiser Permanente · USMaimonides Medical Center · USMedical College of Wisconsin · USNew York University · USUniversity of California, San Francisco · USUniversity of Mississippi Medical Center · USUniversity of North Carolina at Chapel Hill · USVanderbilt University Medical Center · US
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul A. Goepfert · 1988 to 2026
$84.1M
Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0M
QAQC Johns Hopkins Institute for Clinical and Translational ResearchUL1TR003098 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2019 to 2023
$57.7M
Maternal Morbidity and Mortality: Risk Factors, Early Detection and Personalized InterventionUL1TR001409 · NCATS · GEORGETOWN UNIVERSITY · PI GONDRE-LEWIS, MARJORIE C, MELLMAN, THOMAS A · 2015 to 2024
$37.8M
SF Bay Area MACS/WIHS Combined Cohort StudyU01HL146242 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Bradley E Aouizerat, Jennifer Cohen Price · 2019 to 2026
$36.3M
Sex differences in the role of multi-omicsin HIV-associated carotid artery atherosclerosisU01HL146193 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Stephen J Gange, Elizabeth Topper · 2019 to 2026
$35.8M
University of Miami Developmental Center for AIDS Research (D-CFAR)P30AI073961 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Savita Pahwa · 2007 to 2026
$33.8M
Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center - Admin Supplement: Vision and dual sensory loss in HIV-infected older adultsU01HL146201 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TODD T BROWN, Joseph B. Margolick · 2019 to 2026
$33.7M
Sex differences in the role of multi-omics in HIV-associated carotid artery atherosclerosisU01HL146204 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI David B. Hanna, Anjali Sharma · 2019 to 2026
backgroundCervical cancer oncogenesis starts with human papillomavirus (HPV) cell entry after binding to host cell surface receptors; however, the mechanism is not fully known. We examined polymorphisms in receptor genes hypothesized to be necessary for HPV cell entry and assessed their associations with clinical progression to precancer.
methodsAfrican American women (N = 1,728) from the MACS/WIHS Combined Cohort Study were included. Two case-control study designs were used-cases with histology-based precancer (CIN3+) and controls without; and cases with cytology-based precancer [high-grade squamous intraepithelial lesions (HSIL)] and controls without. SNPs in candidate genes (SDC1, SDC2, SDC3, SDC4, GPC1, GPC2, GPC3, GPC4, GPC5, GPC6, and ITGA6) were genotyped using an Illumina Omni2.5-quad beadchip. Logistic regression was used to assess the associations in all participants and by HPV genotypes, after adjusting for age, human immunodeficiency virus serostatus, CD4 T cells, and three principal components for ancestry.
resultsMinor alleles in SNPs rs77122854 (SDC3), rs73971695, rs79336862 (ITGA6), rs57528020, rs201337456, rs11987725 (SDC2), rs115880588, rs115738853, and rs9301825 (GPC5) were associated with increased odds of both CIN3+ and HSIL, whereas, rs35927186 (GPC5) was found to decrease the odds for both outcomes (P value ≤ 0.01). Among those infected with Alpha-9 HPV types, rs722377 (SDC3), rs16860468, rs2356798 (ITGA6), rs11987725 (SDC2), and rs3848051 (GPC5) were associated with increased odds of both precancer outcomes.
conclusionsPolymorphisms in genes that encode binding receptors for HPV cell entry may play a role in cervical precancer progression. IMPACT: Our findings are hypothesis generating and support further exploration of mechanisms of HPV entry genes that may help prevent progression to cervical precancer.
Indexed as
Papillomavirus InfectionsUterine Cervical DysplasiaUterine Cervical NeoplasmsCase-Control StudiesCohort StudiesFemaleGlypicansHuman Papillomavirus VirusesHumansPapillomaviridaePolymorphism, Single NucleotideGlypicansGPC3 protein, humanGPC5 protein, human
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Variations in Genes Encoding Human Papillomavirus Binding Receptors and Susceptibility to Cervical Precancer. · full record | OpenQuestion