Evidence map›Paper›PMID 37410078›Full record

ArticleeLife2023

The evolutionary mechanism of non-carbapenemase carbapenem-resistant phenotypes in

Natalia C Rosas, Jonathan Wilksch, Jake Barber, Jiahui Li, Yanan Wang, Zhewei Sun, Andrea Rocker, Chaille T Webb, Laura Perlaza-Jiménez, Christopher J Stubenrauch and 9 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 14 citations in OpenAlex.

  1. Molecular Epidemiology ofMicroorganisms · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. A 46-week outbreak of ertapenem-resistant, non-carbapenemase encodingEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025
    Article
  7. Review
  8. Article
  9. High diversity of strain clonality and metallo-β-lactamases genes among carbapenem-resistant Enterobacterales in Taiwan.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Article
  10. Article
  11. Article
  12. Molecular insights into the evolutionary trajectory of aAntimicrobial agents and chemotherapy · 2024
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 5 countries.

Natalia C Rosas *Centre to Impact AMR, Monash University, Clayton, Australia.ORCID 0000-0003-2343-2394
Jonathan Wilksch *Centre to Impact AMR, Monash University, Clayton, Australia.
Jake Barber *Centre to Impact AMR, Monash University, Clayton, Australia.ORCID 0000-0001-9279-7763
Jiahui LiCentre to Impact AMR, Monash University, Clayton, Australia.
Yanan WangCentre to Impact AMR, Monash University, Clayton, Australia.
Zhewei SunWenzhou Medical University, Wenzhou, China.
Andrea RockerInfection Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia.
Chaille T WebbCentre to Impact AMR, Monash University, Clayton, Australia.
Laura Perlaza-JiménezCentre to Impact AMR, Monash University, Clayton, Australia.
Christopher J StubenrauchCentre to Impact AMR, Monash University, Clayton, Australia.ORCID 0000-0003-4388-3184
Vijaykrishna DhanasekaranCentre to Impact AMR, Monash University, Clayton, Australia.ORCID 0000-0003-3293-6279
Jiangning SongCentre to Impact AMR, Monash University, Clayton, Australia.
George TaiaroaDepartment of Microbiology and Immunology, The Peter Doherty Institute, The University of Melbourne, Melbourne, Australia.
Mark DaviesDepartment of Microbiology and Immunology, The Peter Doherty Institute, The University of Melbourne, Melbourne, Australia.
Richard A StrugnellDepartment of Microbiology and Immunology, The Peter Doherty Institute, The University of Melbourne, Melbourne, Australia.
Qiyu BaoWenzhou Medical University, Wenzhou, China.
Tieli ZhouThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Michael J McDonaldCentre to Impact AMR, Monash University, Clayton, Australia.ORCID 0000-0002-5735-960X
Trevor LithgowCentre to Impact AMR, Monash University, Clayton, Australia.
Discovery Institute · USWenzhou Medical University · CNImpact · CAThe University of Melbourne · AU

Funding

National Health and Medical Research Council 1092262
6 · The paper itself

Abstract

Antibiotic resistance is driven by selection, but the degree to which a bacterial strain's evolutionary history shapes the mechanism and strength of resistance remains an open question. Here, we reconstruct the genetic and evolutionary mechanisms of carbapenem resistance in a clinical isolate of

Indexed as

CarbapenemsKlebsiella pneumoniaeAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesKlebsiellaMicrobial Sensitivity TestsPhenotypeAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesCarbapenemsantimicrobial resistanceevolutionary biologyKlebsiella quasipneumoniaenon-carbapenemase carbapenem resistance

Identifiers

PMID37410078
PMCPMC10325707
OpenAlexW4383303014

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.