Evidence map›Paper›PMID 37409934›Full record

ArticleMicrobiology spectrum2023

The Existing Drug Nifuroxazide as an Antischistosomal Agent:

Vinícius Roquini, Ana C Mengarda, Rayssa A Cajas, Milene F Martins-da-Silva, Julia Godoy-Silva, Gustavo A Santos, Maria Cristina C Espírito-Santo, Thais F A Pavani, Vanusa A Melo, Maria C Salvadori and 3 more

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Molecules (Basel, Switzerland) · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Antihistamines HACS omega · 2024
    Article
  9. Antimicrobial agents and chemotherapy · 2024
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Vinícius RoquiniResearch Center on Neglected Diseases, Guarulhos University, Guarulhos, São Paulo, Brazil.
Ana C MengardaResearch Center on Neglected Diseases, Guarulhos University, Guarulhos, São Paulo, Brazil.
Rayssa A CajasResearch Center on Neglected Diseases, Guarulhos University, Guarulhos, São Paulo, Brazil.
Milene F Martins-da-SilvaResearch Center on Neglected Diseases, Guarulhos University, Guarulhos, São Paulo, Brazil.
Julia Godoy-SilvaResearch Center on Neglected Diseases, Guarulhos University, Guarulhos, São Paulo, Brazil.
Gustavo A SantosResearch Center on Neglected Diseases, Guarulhos University, Guarulhos, São Paulo, Brazil.
Maria Cristina C Espírito-SantoLaboratory of Immunopathology of Schistosomiasis (LIM-06), Department of Infectious and Parasitic Diseases, Faculty of Medicine, University of São Paulo, São Paulo, São Paulo, Brazil.
Thais F A PavaniBiological Chemistry Post-Graduate Course, Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo, Diadema, São Paulo, Brazil.
Vanusa A MeloBiological Chemistry Post-Graduate Course, Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo, Diadema, São Paulo, Brazil.
Maria C SalvadoriInstitute of Physics, University of São Paulo, São Paulo, São Paulo, Brazil.
Fernanda S TeixeiraInstitute of Physics, University of São Paulo, São Paulo, São Paulo, Brazil.
Daniela G G RandoChemico-Pharmaceutical Research Group, Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo, Diadema, São Paulo, Brazil.
Josué de MoraesResearch Center on Neglected Diseases, Guarulhos University, Guarulhos, São Paulo, Brazil.ORCID 0000-0003-1766-7031
Guarulhos University · BRUniversidade de São Paulo · BRUniversidade Federal de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Schistosomiasis is a parasitic disease that afflicts approximately 250 million people worldwide. There is an urgent demand for new antiparasitic agents because praziquantel, the only drug available for the treatment of schistosomiasis, is not universally effective and may derail current progress toward the WHO goal of eliminating this disease as a public health problem by 2030. Nifuroxazide (NFZ), an oral nitrofuran antibiotic, has recently been explored to be repurposed for parasitic diseases. Here,

Indexed as

NitrofuransSchistosomiasisSchistosomiasis mansoniSchistosomicidesAnimalsHydroxybenzoatesMiceSchistosoma mansoniSerineThreonineHydroxybenzoatesnifuroxazideNitrofuransSchistosomicidesSerineThreonineanthelmintic agentantibioticdrug discoverydrug repurposingmedicinal chemistryparasitic diseasesschistosomiasis

Identifiers

PMID37409934
PMCPMC10434008
OpenAlexW4383301938

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.