Evidence map›Paper›PMID 37409929›Full record

ArticleAutophagy2023

The potent BECN2-ATG14 coiled-coil interaction is selectively critical for endolysosomal degradation of GPRASP1/GASP1-associated GPCRs.

Xianxiu Qiu, Na Li, Qifan Yang, Shuai Wu, Xiaohua Li, Xuehua Pan, Soh Yamamoto, Xiaozhe Zhang, Jincheng Zeng, Jiahao Liao and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. The ATG14: multi-layer autophagy control and an emerging therapeutic target in cancer.Apoptosis : an international journal on programmed cell death · 2026
    Review
  2. Article
  3. CRL4International journal of biological sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 3 countries.

Xianxiu QiuDepartment of Applied Biology and Chemical Technology, State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hong Kong, P. R. China.ORCID 0000-0003-3218-2331
Na LiDepartment of Applied Biology and Chemical Technology, State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hong Kong, P. R. China.ORCID 0000-0002-8563-0532
Qifan YangState Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, P.R. China.ORCID 0000-0001-7934-5463
Shuai WuDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-1677-0221
Xiaohua LiDepartment of Research and Development, Shenzhen Shiningbiotek Co. Ltd, Shenzhen, P. R. China.ORCID 0000-0002-8051-2617
Xuehua PanShenzhen Pengcheng Biopharm Co. Ltd, Shenzhen, P.R. China.ORCID 0000-0002-7163-7581
Soh YamamotoDepartment of Cell and Molecular Biology, Feingberg School of Medicine, Northwestern University, Chicago, IL, USA.
Xiaozhe ZhangDepartment of Applied Biology and Chemical Technology, State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hong Kong, P. R. China.ORCID 0000-0002-3713-8041
Jincheng ZengGuangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research, the First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, P.R. China.ORCID 0000-0001-6196-3917
Jiahao LiaoGuangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research, the First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, P.R. China.
Congcong HeDepartment of Cell and Molecular Biology, Feingberg School of Medicine, Northwestern University, Chicago, IL, USA.
Renxiao WangDepartment of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, People's Republic of China.
Yanxiang ZhaoDepartment of Applied Biology and Chemical Technology, State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hong Kong, P. R. China.ORCID 0000-0002-9408-9979
Hong Kong Polytechnic University · HKGuangdong Medical College · CNNorthwestern University · USChinese Academy of Sciences · CNFudan University · CNJohns Hopkins University · US

Funding

Mechanism of Autophagy Activation in the Prevention of Type 2 DiabetesR01DK113170 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HE, CONGCONG · 2017 to 2025
$3.6M
Autophagic regulation of cocaine abuseR01DA056720 · NIDA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Congcong He, Ming Xu · 2022 to 2026
$2.8M
Autophagy-facilitated secretion in metabolic maintenanceR01DK123447 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HE, CONGCONG · 2021 to 2024
$1.6M
NIDA NIH HHS R01 DA056720NIDDK NIH HHS R01 DK113170NIDDK NIH HHS R01 DK123447
6 · The paper itself

Abstract

abbreviationsAMBRA1 autophagy and beclin 1 regulator 1; ATG14 autophagy related 14; ATG5 autophagy related 5; ATG7 autophagy related 7; BECN1 beclin 1; BECN2 beclin 2; CC coiled-coil; CQ chloroquine CNR1/CB1R cannabinoid receptor 1 DAPI 4',6-diamidino-2-phenylindole; dCCD delete CCD; DRD2/D2R dopamine receptor D2 GPRASP1/GASP1 G protein-coupled receptor associated sorting protein 1 GPCR G-protein coupled receptor; ITC isothermal titration calorimetry; IP immunoprecipitation; KD knockdown; KO knockout; MAP1LC3/LC3 microtubule associated protein 1 light chain 3; NRBF2 nuclear receptor binding factor 2; OPRD1/DOR opioid receptor delta 1 PIK3C3/VPS34 phosphatidylinositol 3-kinase catalytic subunit type 3; PIK3R4/VPS15 phosphoinositide-3-kinase regulatory subunit 4; PtdIns3K class III phosphatidylinositol 3-kinase; PtdIns3P phosphatidylinositol-3-phosphate; RUBCN rubicon autophagy regulator; SQSTM1/p62 sequestosome 1; UVRAG UV radiation resistance associated; VPS vacuolar protein sorting; WT wild type.

Indexed as

Autophagy-Related ProteinsEndosomesLysosomesReceptors, G-Protein-CoupledAdaptor Proteins, Vesicular TransportAnimalsAutophagyBeclin-1HEK293 CellsHumansMiceProtein BindingProteolysisVesicular Transport ProteinsAdaptor Proteins, Vesicular TransportATG14 protein, humanAtg14 protein, mouseAutophagy-Related ProteinsBeclin-1Receptors, G-Protein-CoupledVesicular Transport ProteinsATG14autophagyBECN2coiled-coilPtdIns3K

Identifiers

PMID37409929
PMCPMC10549190
OpenAlexW4383302020

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.