Evidence map›Paper›PMID 37409832›Full record

ArticlemBio2023

Insights into the role of HIV-1 Vpu in modulation of NF-ĸB signaling pathways.

Robert Z Zhang, Melissa Kane

Open access · goldAbstract readComment
In one paragraph

Article in mBio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Robert Z ZhangDepartment of Pediatrics, Division of Infectious Diseases, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-7429-2024
Melissa KaneDepartment of Pediatrics, Division of Infectious Diseases, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-4580-1210
University of Pittsburgh · US

Funding

Viral Persistence and PathogenesisT32AI049820 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DELUCA, NEAL A. · 2001 to 2024
$5.5M
NIAID NIH HHS T32 AI049820
6 · The paper itself

Abstract

HIV-1 inhibits the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) to prevent the induction of a proinflammatory state but also activates the NF-κB pathway to promote viral transcription. Thus, optimal regulation of this pathway is important for the viral life cycle. In recent work, Pickering et al

Indexed as

HIV-1NF-kappa BSignal TransductionNF-kappa BHIV-1NF-κBVpuβ-TrCP1

Identifiers

PMID37409832
PMCPMC10470773
OpenAlexW4383302790

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.