Evidence map›Paper›PMID 37409810›Full record

ArticlemBio2023

S2P intramembrane protease RseP degrades small membrane proteins and suppresses the cytotoxicity of intrinsic toxin HokB.

Tatsuhiko Yokoyama, Yutaro Yamagata, Saisei Honna, Shinya Mizuno, Shizuka Katagiri, Rika Oi, Terukazu Nogi, Yohei Hizukuri, Yoshinori Akiyama

Open access · goldAbstract read
In one paragraph

Article in mBio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Cleavage cascade of the sigma regulator FecR orchestrates TonB-dependent signal transduction.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Tatsuhiko YokoyamaInstitute for Life and Medical Sciences, Kyoto University, Sakyo-ku , Kyoto, Japan.ORCID 0000-0003-3122-6822
Yutaro YamagataInstitute for Life and Medical Sciences, Kyoto University, Sakyo-ku , Kyoto, Japan.
Saisei HonnaInstitute for Life and Medical Sciences, Kyoto University, Sakyo-ku , Kyoto, Japan.
Shinya MizunoInstitute for Life and Medical Sciences, Kyoto University, Sakyo-ku , Kyoto, Japan.
Shizuka KatagiriGraduate School of Medical Life Science, Yokohama City University, Tsurumi-ku , Yokohama, Japan.
Rika OiGraduate School of Medical Life Science, Yokohama City University, Tsurumi-ku , Yokohama, Japan.
Terukazu NogiGraduate School of Medical Life Science, Yokohama City University, Tsurumi-ku , Yokohama, Japan.ORCID 0000-0001-8663-3519
Yohei HizukuriInstitute for Life and Medical Sciences, Kyoto University, Sakyo-ku , Kyoto, Japan.ORCID 0000-0003-0594-1160
Yoshinori AkiyamaInstitute for Life and Medical Sciences, Kyoto University, Sakyo-ku , Kyoto, Japan.ORCID 0000-0003-4483-5408
Kyoto University · JPYokohama City University · JP

Funding

Cooperative Research Program (Joint Usage/Research Centerprogram) of the Institute for Frontier Life and Medical Sciences Kyoto University N.A.Institute for Fermentation, Osaka (IFO) G-2022-2-108Institute for Frontier Life and Medical Sciences, Kyoto University for INFRONT Office of Director's Research Grant Program (2020) N.A.Institute for Frontier Life and Medical Sciences, Kyoto University for INFRONT Office of Director's Research Grant Program (2021) N.A.MEXT | Japan Society for the Promotion of Science (JSPS) JP18H02404MEXT | Japan Society for the Promotion of Science (JSPS) JP19H03170MEXT | Japan Society for the Promotion of Science (JSPS) JP19K06562MEXT | Japan Society for the Promotion of Science (JSPS) JP21J15841MEXT | Japan Society for the Promotion of Science (JSPS) JP22H02561MEXT | Japan Society for the Promotion of Science (JSPS) JP22H02571MEXT | Japan Society for the Promotion of Science (JSPS) JP22K06142MEXT | Japan Society for the Promotion of Science (JSPS) JP26291016Platform Project for Supporting in Drug Discovery and Life Science Research form the Japan Agency for Medical Research and Development JP16am0101020
6 · The paper itself

Abstract

The site2

Indexed as

Bacterial ToxinsEscherichia coliEscherichia coli ProteinsMembrane ProteinsSerine EndopeptidasesEndopeptidasesGene Expression Regulation, BacterialProteolysisBacterial ToxinsEndopeptidasesEscherichia coli ProteinsMembrane ProteinsRseP protein, E coliSerine Endopeptidasesextracytoplasmic stress responsemembrane proteaseproteostasisregulated intramembrane proteolysiszinc metallopeptidase

Identifiers

PMID37409810
PMCPMC10470546
OpenAlexW4383302383

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.