Evidence map›Paper›PMID 37409809›Full record

ArticlemBio2023

Ergosterol distribution controls surface structure formation and fungal pathogenicity.

Hau Lam Choy, Elizabeth A Gaylord, Tamara L Doering

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in mBio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Cellular and molecular responses ofMicrobiology spectrum · 2026
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  8. Article
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  11. Review
  12. Article
  13. Cryptococcus.Current biology : CB · 2025
    Review
  14. Molecular Mechanism of Aflatoxin BJournal of fungi (Basel, Switzerland) · 2025
    Article
  15. Review
  16. Article
  17. Different Symbiotic Species ofMicroorganisms · 2025
    Article
  18. Article
  19. Antifungal efficacy and mechanisms ofFrontiers in plant science · 2025
    Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Hau Lam ChoyDepartment of Molecular Microbiology, Washington University School of Medicine , St. Louis, Missouri, USA.ORCID 0000-0002-7813-4880
Elizabeth A GaylordDepartment of Molecular Microbiology, Washington University School of Medicine , St. Louis, Missouri, USA.ORCID 0000-0003-3992-3526
Tamara L DoeringDepartment of Molecular Microbiology, Washington University School of Medicine , St. Louis, Missouri, USA.ORCID 0000-0002-5179-7393
Washington University in St. Louis · US

Funding

TRAINING PROGRAM IN CELLULAR AND MOLECULAR BIOLOGYT32GM007067 · NIGMS · WASHINGTON UNIVERSITY · PI TRUE-KROB, HEATHER L · 1985 to 2020
$20.4M
CRYPTOCOCCAL GLYCAN SYNTHESISR01AI135012 · NIAID · WASHINGTON UNIVERSITY · PI DOERING, TAMARA L · 2018 to 2022
$2.5M
MITOCHONDRIAL REGULATION IN CRYPTOCOCCUS NEOFORMANSR21AI136688 · NIAID · WASHINGTON UNIVERSITY · PI DOERING, TAMARA L · 2018 to 2019
$429k
Cryptococcal factors in host cell interactionsR21AI140979 · NIAID · WASHINGTON UNIVERSITY · PI DOERING, TAMARA L · 2018 to 2019
$428k
Leveraging genomic approaches to define sterol transport in Cryptococcus neoformansR21AI178330 · NIAID · WASHINGTON UNIVERSITY · PI DOERING, TAMARA L · 2023 to 2024
$428k
NIAID NIH HHS R01 AI135012NIAID NIH HHS R21 AI136688NIAID NIH HHS R21 AI140979NIAID NIH HHS R21 AI178330NIGMS NIH HHS T32 GM007067
6 · The paper itself

Abstract

Ergosterol, the major sterol in fungal membranes, is critical for defining membrane fluidity and regulating cellular processes. Although ergosterol synthesis has been well defined in model yeast, little is known about sterol organization in the context of fungal pathogenesis. We identified a retrograde sterol transporter, Ysp2, in the opportunistic fungal pathogen

Indexed as

CryptococcosisCryptococcus neoformansAntifungal AgentsErgosterolFluconazoleFungal ProteinsHumansMembrane Transport ProteinsSaccharomyces cerevisiaeSterolsVirulenceAntifungal AgentsErgosterolFluconazoleFungal ProteinsMembrane Transport ProteinsSterolsCryptococcus neoformansergosterolmycologysterol transportvirulenceYsp2

Identifiers

PMID37409809
PMCPMC10470819
OpenAlexW4383301675

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.