Evidence map›Paper›PMID 37409735›Full record

ArticleJournal of biomolecular structure & dynamics2024

Identification of pseudobaptigenin as a novel polyphenol-based multi-target antagonist of different hormone receptors for breast cancer therapeutics.

Sarbajit Ray, Suchetana Gupta, Gayatri Panda, Prarthana Chatterjee, Anoushka Das, Purvi Patawri, Parisa Hosseinzadeh, Arjun Ray, Satarupa Banerjee

Abstract read
In one paragraph

Article in Journal of biomolecular structure & dynamics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Revealing the effects ofFrontiers in microbiology · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sarbajit RayDepartment of Biotechnology, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India.
Suchetana GuptaDepartment of Bioengineering, Phil and Penny Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR, USA.
Gayatri PandaDepartment of Computational Biology, Indraprastha Institute of Information Technoloy, New Delhi, India.
Prarthana ChatterjeeDepartment of Biotechnology, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India.
Anoushka DasDepartment of Biotechnology, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India.
Purvi PatawriDepartment of Biotechnology, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India.
Parisa HosseinzadehDepartment of Bioengineering, Phil and Penny Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR, USA.
Arjun RayDepartment of Computational Biology, Indraprastha Institute of Information Technoloy, New Delhi, India.
Satarupa BanerjeeDepartment of Biotechnology, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India.

Funding

A data-driven approach towards generation of permeable peptide therapeuticsDP2GM146249 · NIGMS · UNIVERSITY OF OREGON · PI HOSSEINZADEH, PARISA · 2021 to 2024
$2.2M
NIGMS NIH HHS DP2 GM146249
6 · The paper itself

Abstract

Breast cancer (BC) is one of the most prevalent cancers in the world and is one of the major reasons for the death of women worldwide. BC is majorly categorized based on the presence or absence of three cell receptors ER, PR and HER2. The latest treatment for BC involves interfering with the production and action of hormones such as estrogen and progesterone. These hormones bind with receptors such as ER and PR and enhance the growth and proliferation of the BC cells. Although the available are effective, the increasing resistance and side effects related to hormonal imbalance are significant and hence there is a need for designing. On the other hand, plant-derivative products have gained a lot of popularity for their promising anti-cancerous activities. Polyphenols are one such group of plant derivatives that have proven to be useful against cancer. In the present study, an

Indexed as

Breast NeoplasmsMolecular Docking SimulationMolecular Dynamics SimulationPolyphenolsReceptors, EstrogenReceptors, ProgesteroneAntineoplastic AgentsBinding SitesErb-b2 Receptor Tyrosine KinasesFemaleHumansProtein BindingAntineoplastic AgentsErb-b2 Receptor Tyrosine KinasesPolyphenolsReceptors, EstrogenReceptors, ProgesteroneADMETBreast cancerestrogen receptorHER2 receptormolecular dockingmolecular dynamics simulationpolyphenolsprogesterone receptor

Identifiers

PMID37409735
PMCPMC12680423

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.