ArticleNMR in biomedicine2023
Age and gender differences in lumbar intervertebral disk strain using mechanical loading magnetic resonance imaging.
Article in NMR in biomedicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- Human In Vivo Disc Mechanics in Flexion, Extension, and Diurnal Loading With Aging and Degeneration.JOR spine · 2026Article
- Mechano-immune interactions in musculoskeletal aging: Mechanisms and translational perspectives.Theranostics · 2026Review
- Advances in mechanical assessments of in vivo human lumbar spine tissues with noninvasive imaging techniques.npj biomedical innovations · 2026Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The objective of the current study was to investigate age- and gender-related differences in lumbar intervertebral disk (IVD) strain with the use of static mechanical loading and continuous three-dimensional (3D) golden-angle radial sparse parallel (GRASP) MRI. A continuous 3D-GRASP stack-of-stars trajectory of the lumbar spine was performed on a 3-T scanner with static mechanical loading. Compressed sensing reconstruction, motion deformation maps, and Lagrangian strain maps during loading and recovery in the X-, Y-, and Z-directions were calculated for segmented IVD segments from L1/L2 to L5/S1. Mean IVD height was measured at rest. Spearman coefficients were used to evaluate the associations between age and global IVD height and global IVD strain. Mann-Whitney tests were used to compare global IVD height and global IVD strain in males and females. The prospective study enrolled 20 healthy human volunteers (10 males, 10 females; age 34.6 ± 11.4 [mean ± SD], range 22-56 years). Significant increases in compressive strain were observed with age, as evidenced by negative correlations between age and global IVD strain during loading (ρ = -0.76, p = 0.0046) and recovery (ρ = -0.68, p = 0.0251) in the loading X-direction. There was no significant correlation between age and global IVD height, global IVD strain during loading and recovery in the Y-direction, and global IVD strain during loading and recovery in the Z-direction. There were no significant differences between males and females in global IVD height and global IVD strain during loading and recovery in the X-, Y-, and Z-directions. It was concluded that our study demonstrated the significant role aging plays in internal dynamic strains in the lumbar IVD during loading and recovery. Older healthy individuals have reduced IVD stiffness and greater IVD compression during static mechanical loading of the lumbar spine. The GRASP-MRI technique demonstrates the feasibility to identify changes in IVD mechanical properties with early IVD degeneration due to aging.
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Registered trials
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