Evidence map›Paper›PMID 37409576›Full record

ArticleBiomaterials science2023

Polymer/copper nanocomplex-induced lysosomal cell death promotes tumor lymphocyte infiltration and synergizes anti-PD-L1 immunotherapy for triple-negative breast cancer.

Xiangxiang Hu, Mingming Wang, Shanshan Shi, Manikanda Keerthi Raja, Gourab Gupta, Hexin Chen, Peisheng Xu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. The role of metal ions iron, copper, and zinc in the immune microenvironment of gastric cancer.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xiangxiang HuDepartment of Drug Discovery and Biomedical Sciences, University of South Carolina, 715 Sumter St., Columbia, SC 29208, USA. xup@cop.sc.edu.
Mingming WangDepartment of Drug Discovery and Biomedical Sciences, University of South Carolina, 715 Sumter St., Columbia, SC 29208, USA. xup@cop.sc.edu.
Shanshan ShiDepartment of Drug Discovery and Biomedical Sciences, University of South Carolina, 715 Sumter St., Columbia, SC 29208, USA. xup@cop.sc.edu.
Manikanda Keerthi RajaDepartment of Biological Sciences, University of South Carolina, 715 Sumter St., Columbia, SC 29208, USA.
Gourab GuptaDepartment of Biological Sciences, University of South Carolina, 715 Sumter St., Columbia, SC 29208, USA.
Hexin ChenDepartment of Biological Sciences, University of South Carolina, 715 Sumter St., Columbia, SC 29208, USA.
Peisheng XuDepartment of Drug Discovery and Biomedical Sciences, University of South Carolina, 715 Sumter St., Columbia, SC 29208, USA. xup@cop.sc.edu.ORCID http://orcid.org/0000-0002-4486-7058
University of South Carolina Sumter · US

Funding

Cancer cell selective killing nanoparticle for advanced ovarian cancer treatmentR01CA263747 · NCI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI Peisheng Xu · 2022 to 2026
$1.7M
Nanoparticle delivered miR-489 rejuvenates anthracycline-based chemotherapyR21CA252360 · NCI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI CHEN, HEXIN, XU, PEISHENG · 2020 to 2021
$397k
NCI NIH HHS R01 CA263747NCI NIH HHS R21 CA252360
6 · The paper itself

Abstract

Our previous research discovered that combining the PDA-PEG polymer with copper ions can selectively kill cancer cells. However, the precise mechanism by which this combination functions was not fully understood. This study revealed that the PDA-PEG polymer and copper ions form complementary PDA-PEG/copper (Poly/Cu) nanocomplexes by facilitating copper ion uptake and lysosomal escape. An

Indexed as

PolymersTriple Negative Breast NeoplasmsCell DeathCell Line, TumorCopperHumansImmunotherapyLymphocytesLysosomesCopperPolymers

Identifiers

PMID37409576
PMCPMC10530473
OpenAlexW4382133520

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.