Evidence map›Paper›PMID 37409455›Full record

ArticleCirculation. Genomic and precision medicine2023

Contemporary Polygenic Scores of Low-Density Lipoprotein Cholesterol and Coronary Artery Disease Predict Coronary Atherosclerosis in Adolescents and Young Adults.

Rodrigo Guarischi-Sousa, Elias Salfati, Pik Fang Kho, Kruthika R Iyer, Austin T Hilliard, David M Herrington, Philip S Tsao, Shoa L Clarke, Themistocles L Assimes

Open access · hybridAbstract read
In one paragraph

Article in Circulation. Genomic and precision medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

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  5. A cardiovascular risk model validated in Japan applied to an Italian cohort: Procedere con prudenza.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Rodrigo Guarischi-SousaDepartment of Medicine, Division of Cardiovascular Medicine (R.G.-S., P.F.K., K.R.I., P.S.T., S.L.C., T.L.A.).ORCID 0000-0002-3614-9996
Elias SalfatiScripps Research Translational Institute at Scripps Research, La Jolla, CA (E.S.).
Pik Fang KhoDepartment of Medicine, Division of Cardiovascular Medicine (R.G.-S., P.F.K., K.R.I., P.S.T., S.L.C., T.L.A.).ORCID 0000-0001-7831-6062
Kruthika R IyerDepartment of Medicine, Division of Cardiovascular Medicine (R.G.-S., P.F.K., K.R.I., P.S.T., S.L.C., T.L.A.).
Austin T HilliardVA Palo Alto Health Care System, CA (A.T.H., P.S.T., S.L.C., T.L.A.).
David M HerringtonDepartment of Internal Medicine, Section on Cardiovascular Medicine, Wake Forest School of Medicine, Winston-Salem, NC (D.M.H.).
Philip S TsaoDepartment of Medicine, Division of Cardiovascular Medicine (R.G.-S., P.F.K., K.R.I., P.S.T., S.L.C., T.L.A.).ORCID 0000-0001-7274-9318
Shoa L Clarke *Department of Medicine, Division of Cardiovascular Medicine (R.G.-S., P.F.K., K.R.I., P.S.T., S.L.C., T.L.A.).ORCID 0000-0002-6592-1172
Themistocles L Assimes *Department of Medicine, Division of Cardiovascular Medicine (R.G.-S., P.F.K., K.R.I., P.S.T., S.L.C., T.L.A.).ORCID 0000-0003-2349-0009
VA Palo Alto Health Care System · USScripps Research Institute · USWake Forest University · US

Funding

Polygenic Risk Scores for Diverse Populations - Bridging Research and Clinical CareR01HL151152 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Christy Leigh Avery, Jennifer Below · 2020 to 2026
$12.3M
Institutional Career Development Core (KL2)KL2TR003143 · NCATS · STANFORD UNIVERSITY · PI ASCH, STEVEN M. · 2019 to 2023
$8.7M
SNPs and Extent of Atherosclerosis (SEA) StudyU01HL080443 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HERRINGTON, DAVID MCLEOD · 2006 to 2009
$8.7M
Proteomic determinants of direct measures of insulin sensitivityR01DK114183 · NIDDK · STANFORD UNIVERSITY · PI ASSIMES, THEMISTOCLES LEONARD · 2018 to 2022
$3.5M
New methods for constructing and evaluating polygenic scoresR01HG011432 · NHGRI · STANFORD UNIVERSITY · PI PRITCHARD, JONATHAN K · 2020 to 2023
$3.3M
NCATS NIH HHS KL2 TR003143NHGRI NIH HHS R01 HG011432NHLBI NIH HHS R01 HL151152NHLBI NIH HHS U01 HL080443NIDDK NIH HHS R01 DK114183
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Coronary Artery DiseaseAdolescentCholesterol, HDLCholesterol, LDLHumansRisk FactorsYoung AdultCholesterol, HDLCholesterol, LDLcoronary artery diseasegenetic predisposition to diseasegenetic testinglow density lipoproteinprecision medicineprimary preventionyoung adults

Identifiers

PMID37409455
PMCPMC10581412
OpenAlexW4383303066

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.