Evidence map›Paper›PMID 37409411›Full record

ArticleTissue engineering. Part C, Methods2023

Microfluidic Platform for Microparticle Fabrication and Release of a Cathepsin Inhibitor.

Elda A Treviño, Jimmy Shah, Joseph J Pearson, Manu O Platt, Younan Xia, Johnna S Temenoff

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tissue engineering. Part C, Methods, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Elda A TreviñoWallace H. Coulter Department of Biomedical Engineering, Georgia Tech/Emory University, Atlanta, Georgia, USA.
Jimmy ShahWallace H. Coulter Department of Biomedical Engineering, Georgia Tech/Emory University, Atlanta, Georgia, USA.
Joseph J PearsonWallace H. Coulter Department of Biomedical Engineering, Georgia Tech/Emory University, Atlanta, Georgia, USA.
Manu O PlattWallace H. Coulter Department of Biomedical Engineering, Georgia Tech/Emory University, Atlanta, Georgia, USA.
Younan XiaWallace H. Coulter Department of Biomedical Engineering, Georgia Tech/Emory University, Atlanta, Georgia, USA.
Johnna S TemenoffWallace H. Coulter Department of Biomedical Engineering, Georgia Tech/Emory University, Atlanta, Georgia, USA.
Georgia Institute of Technology · USThe Wallace H. Coulter Department of Biomedical Engineering · US

Funding

Injectable Biomaterials to Modulate Protease Activity in TendinopathyR01AR063692 · NIAMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI TEMENOFF, JOHNNA S · 2013 to 2017
$1.5M
NIAMS NIH HHS R01 AR063692
6 · The paper itself

Abstract

Cathepsins are a family of cysteine proteases responsible for a variety of homeostatic functions throughout the body, including extracellular matrix remodeling, and have been implicated in a variety of degenerative diseases. However, clinical trials using systemic administration of cathepsin inhibitors have been abandoned due to side effects, so local delivery of cathepsin inhibitors may be advantageous. In these experiments, a novel microfluidic device platform was developed that can synthesize uniform, hydrolytically degradable microparticles from a combination of poly(ethylene glycol) diacrylate (PEGDA) and dithiothreitol (DTT). Of the formulations examined, the 10-polymer weight percentage 10 mM DTT formulation degraded after 77 days

Indexed as

CathepsinsMicrofluidicsPolyethylene GlycolsPolymersCathepsinspoly(ethylene glycol)diacrylatePolyethylene GlycolsPolymerscathepsinmicrofluidic devicemicroparticlepoly(ethylene glycol)sustained release

Identifiers

PMID37409411
PMCPMC10442676
OpenAlexW4383302699

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.