Evidence map›Paper›PMID 37408903›Full record

ArticleHeliyon2023

Clinicopathological characteristics of endometrial carcinomas according to DNA mismatch repair protein status.

Daniela de Freitas, Fernando Nalesso Aguiar, Cristina Anton, Danielle Cristina de Almeida, Carlos Eduardo Bacchi, Jesus Paula Carvalho, Filomena Marino Carvalho

Open access · goldAbstract read
In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Associations between molecular subtypes and high-risk pathological factors in endometrial cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. GermlineGynecologic oncology reports · 2024
    Article
  10. Article
  11. Article
  12. Immune checkpoint inhibitors: here to stay.Translational cancer research · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Daniela de FreitasInstituto do Cancer do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Arnaldo, 251, ZIP code 01246-000, Sao Paulo, SP, Brazil.
Fernando Nalesso AguiarInstituto do Cancer do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Arnaldo, 251, ZIP code 01246-000, Sao Paulo, SP, Brazil.
Cristina AntonInstituto do Cancer do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Arnaldo, 251, ZIP code 01246-000, Sao Paulo, SP, Brazil.
Danielle Cristina de AlmeidaConsultoria em Patologia, Rua Major Leônidas Cardoso, 739, ZIP code 18602-010, Botucatu, SP, Brazil.
Carlos Eduardo BacchiConsultoria em Patologia, Rua Major Leônidas Cardoso, 739, ZIP code 18602-010, Botucatu, SP, Brazil.
Jesus Paula CarvalhoInstituto do Cancer do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Arnaldo, 251, ZIP code 01246-000, Sao Paulo, SP, Brazil.
Filomena Marino CarvalhoDepartment of Pathology, Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Arnaldo, 455, room 1465, ZIP code 01246-903, Sao Paulo, SP, Brazil.
Universidade de São Paulo · BRLaboratório Bacchi · BRHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA mismatch repair protein deficiency (MMRd) in endometrial carcinoma is associated with the risk of Lynch syndrome and response to immune checkpoint inhibitors. It is also related to microsatellite instability and corresponds to a molecular subtype of endometrial tumor with an unclear prognosis. Here, we evaluated the clinicopathological characteristics and prognosis of 312 consecutive endometrial carcinoma cases submitted to complete surgical staging at a single institution. We compared MMRd and mismatch repair protein-proficient (MMRp) tumors and examined the effects of the MMR protein loss type (MLH1/PMS2 vs. MSH2/MSH6) and influence of L1CAM and p53 expression. The median follow-up period was 54.5 (range, 0-120.5) months. No difference was observed between MMRd [

Indexed as

DNA mismatch repair proteinEndometrial carcinomaL1CAMp53Prognosis

Identifiers

PMID37408903
PMCPMC10319187
OpenAlexW4381686659

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.