ArticleExperimental and therapeutic medicine2023
Inflammation biomarkers IL‑6 and IL‑10 may improve the diagnostic and prognostic accuracy of currently authorized traumatic brain injury tools.
Article in Experimental and therapeutic medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 23 citations in OpenAlex.
- Systemic and cerebro-cardiac biomarkers following traumatic brain injury: an interim analysis of randomized controlled clinical trial of early administration of beta blockers.Scientific reports · 2024Trial
- Effects of surgical timing on inflammatory responses, oxidative stress, and immune modulation in Wagyu calves following castration.BMC veterinary research · 2026Article
- The Role of Cytokines in Traumatic Brain Injury.Biomedicines · 2026Review
- Multi-dimensional plasma proteomic profiling elucidates molecular mechanisms and pathophysiological networks in pediatric severe traumatic brain injury.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Concurrent Toxoplasma gondii infection and neuroinflammation in traumatic brain injury patients in a referral hospital in Douala Cameroon.Scientific reports · 2026Article
- Mapping the acute trajectory of sport-related concussion outcomes across symptoms, cognition, and blood biomarkers.Sports medicine and health science · 2026Review
- Correlation of Routine Admission Inflammatory Biomarkers with Individual Traumatic Brain Lesion Types in Mild Traumatic Brain Injury.Biomedicines · 2026Article
- Cytokines and related signaling pathways in traumatic brain injury.Frontiers in immunology · 2026Review
- Article
- Multifactorial analysis of clinical prognosis in patients with anti-N-methyl-D-aspartate receptor encephalitis: a single-centre cohort study.Internal medicine journal · 2025Article
- Inflammatory proteins as acute biomarkers of post-traumatic epilepsy.Frontiers in neurology · 2025Article
- Plasma profiles of inflammatory cytokines in children with moderate to severe traumatic brain injury: a prospective cohort study.European journal of pediatrics · 2024Article
- Differences in Eotaxin Serum Levels between Polytraumatized Patients with and without Concomitant Traumatic Brain Injury-A Matched Pair Analysis.Journal of clinical medicine · 2024Article
- Pathophysiology-Based Management of Secondary Injuries and Insults in TBI.Biomedicines · 2024Review
- Fluid-Based Protein Biomarkers in Traumatic Brain Injury: The View from the Bedside.International journal of molecular sciences · 2023Review
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traumatic brain injury (TBI) is currently one of the leading causes of mortality and disability worldwide. At present, no reliable inflammatory or specific molecular neurobiomarker exists in any of the standard models proposed for TBI classification or prognostication. Therefore, the present study was designed to assess the value of a group of inflammatory mediators for evaluating acute TBI, in combination with clinical, laboratory and radiological indices and prognostic clinical scales. In the present single-centre, prospective observational study, 109 adult patients with TBI, 20 adult healthy controls and a pilot group of 17 paediatric patients with TBI from a Neurosurgical Department and two intensive care units of University General Hospital of Heraklion, Greece were recruited. Blood measurements using the ELISA method, of cytokines IL-6, IL-8 and IL-10, ubiquitin C-terminal hydrolase L1 (UCH-L1) and glial fibrillary acidic protein, were performed. Compared with those in healthy control individuals, elevated IL-6 and IL-10 but reduced levels of IL-8 were found on day 1 in adult patients with TBI. In terms of TBI severity classifications, higher levels of IL-6 (P=0.001) and IL-10 (P=0.009) on day 1 in the adult group were found to be associated with more severe TBI according to widely used clinical and functional scales. Moreover, elevated IL-6 and IL-10 in adults were found to be associated with more serious brain imaging findings (r
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