Evidence map›Paper›PMID 37408803›Full record

ReviewJournal of clinical and translational hepatology2023

Emerging Therapeutic Strategies in The Fight Against Primary Biliary Cholangitis.

Abigail Medford, Jonathan Childs, Ashleigh Little, Sanjukta Chakraborty, Leonardo Baiocchi, Gianfranco Alpini, Shannon Glaser

Open access · diamondAbstract readReview
In one paragraph

Review in Journal of clinical and translational hepatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Sequence of events leading to primary biliary cholangitis.World journal of gastroenterology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Abigail MedfordDepartment of Medical Physiology, Texas A&M University School of Medicine, Bryan, TX, USA.
Jonathan ChildsDepartment of Medical Physiology, Texas A&M University School of Medicine, Bryan, TX, USA.
Ashleigh LittleDepartment of Medical Physiology, Texas A&M University School of Medicine, Bryan, TX, USA.
Sanjukta ChakrabortyDepartment of Medical Physiology, Texas A&M University School of Medicine, Bryan, TX, USA.
Leonardo BaiocchiHepatology Unit, University of Tor Vergata, Rome, Italy.
Gianfranco AlpiniDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Shannon GlaserDepartment of Medical Physiology, Texas A&M University School of Medicine, Bryan, TX, USA.ORCID https://orcid.org/0000-0002-0749-773X
Bryan College · USTexas A&M University · USIndiana University – Purdue University Indianapolis · USUniversity of Rome Tor Vergata · IT

Funding

Role of STING in Cholestatic Liver InjuryR01DK135881 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI Burcin Ekser, Shannon Stroud Glaser · 2023 to 2026
$1.9M
Regulation of Ductular Reaction by Substance P during Alcohol-induced Liver InjuryR21AA030095 · NIAAA · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI EKSER, BURCIN, GLASER, SHANNON STROUD · 2023 to 2024
$424k
Autocrine/Paracrine Regulation of Intrahepatic Bile Duct GrowthI01BX000574 · VA · RLR VA MEDICAL CENTER · PI ALPINI, GIANFRANCO D · 2009 to 2022
–
BLR&D Research Career Scientist AwardIK6BX004601 · VA · RLR VA MEDICAL CENTER · PI ALPINI, GIANFRANCO D · 2019 to 2025
–
BLRD VA I01 BX000574BLRD VA IK6 BX004601NIAAA NIH HHS R21 AA030095NIDDK NIH HHS R01 DK135881
6 · The paper itself

Abstract

The liver has a vital role in many metabolic and regulatory processes in the body. Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is a chronic cholestatic autoimmune disease of the intrahepatic bile ducts associated with loss of tolerance to mitochondrial antigens. At this time there is no definitive cure for PBC; however, ursodeoxycholic acid (UDCA) has been shown to reduce injury when administered as the first line of treatment. Additional therapeutics can be given concurrently or as an alternative to UDCA to manage the symptoms and further curb disease progression. Currently, a liver transplant is the only potentially curative option when the patient has developed end-stage liver disease or intractable pruritus. This review aims to delineate the pathogenesis of primary biliary cholangitis and shed light on current therapeutic strategies in the treatment of PBC.

Indexed as

Biliary epithelia ursodeoxycholic acidCholestatic liver diseaseTherapeutic approaches

Identifiers

PMID37408803
PMCPMC10318288
OpenAlexW4327614995

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.