ArticleJournal of translational internal medicine2023
A newly-synthesized compound CP-07 alleviates microglia-mediated neuroinflammation and ischemic brain injury via inhibiting STAT3 phosphorylation.
Article in Journal of translational internal medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
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- Lactate modulates microglial M2 polarizationJournal of translational internal medicine · 2026Article
- Expression and clinical significance of growth differentiation factor-15 in vascular cognitive impairment based on bioinformatic analysis.Journal of translational internal medicine · 2026Article
- Smart Nanofibers in Wound Healing: Exploring Novel Combinations and Applications.Current drug delivery · 2026Review
- Utilizing multivariate pattern analysis to uncover the neurobiological underpinnings of communication disorders in children with bilateral spastic cerebral palsy: insights from morphological and structural connectivity changes.Quantitative imaging in medicine and surgery · 2026Article
- Harnessing Ribonucleoprotein Granule Biology for Cancer Therapy: The Central Role of Protein Modifications.Research (Washington, D.C.) · 2026Review
- Examination of Motor Imagery Ability in Individuals With Diplegic Cerebral Palsy: Case-Control Study.Revista de neurologia · 2025Article
- Kaempferol alleviates myocardial ischemia injury by reducing oxidative stress via the HDAC3-mediated Nrf2 signaling pathway.Journal of advanced research · 2025Article
- Association between serum gamma-glutamyltransferase and stroke in adults from national health and nutrition examination survey (2005-2016): a cross-sectional study.BMC cardiovascular disorders · 2025Article
- Lactic acid metabolism: gynecological cancer's Achilles' heel.Discover oncology · 2025Review
- Th22 cells promote the transition from homeostatic to reactive microglia in diabetic encephalopathy.Acta diabetologica · 2025Article
- Drug Repurposing and Screening for Multiple Sclerosis Targeting Microglia and Macrophages.Molecular neurobiology · 2025Article
- Synthesis and evaluation of enzyme inhibition by novel TT01001 derivatives as monoamine oxidase B inhibitors.Bioorganic & medicinal chemistry letters · 2025Article
- Minocycline AmelioratesBrain sciences · 2025Article
- The significance of calcium ions in cerebral ischemia-reperfusion injury: mechanisms and intervention strategies.Frontiers in molecular biosciences · 2025Review
- METTL16 Contributes to Coronary Heart Disease by Inducing TET2 m6A Modification.Journal of inflammation research · 2025Article
- Effect of Carboxymethyl chitosan-sodium alginate hydrogel loaded withFrontiers in pharmacology · 2025Article
- Role of phosphorylated Y1252, Y1336 and Y1472 on NR2B subunits in hypoxia tolerance of neuronal cell in vitro.Experimental brain research · 2024Article
- Piezo1 Modulates Neuronal Autophagy and Apoptosis in Cerebral Ischemia-Reperfusion Injury Through the AMPK-mTOR Signaling Pathway.Neurochemical research · 2024Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Objectives: Overactivated glial cells, especially microglia, are core components in the progression of pathologic neuroinflammation, and the application of anti-inflammatory reagents has been regarded as a potential therapy in the management of infarction/reperfusion (I/R) brain injury. This research aims to clarify the anti-inflammatory efect of a novel lipophilic compound N-(2-[4-tert-butylphenyl]-2-[pyrrolidine-1-yl]ethyl)-7-methyl-4-oxo-4H-chromene-2-carboxamide (named CP-07 in this study) in LPS-stimulated BV2 cell line and primary mouse microglia, and its therapeutic effect on I/R brain injury. Method: Cell Counting Kit-8 assay was used to determine the maximal nontoxic dose of CP-07. The mRNA levels of representative proinflammatory cytokines were determined by quantitative real-time polymerase chain reaction both Results: CP-07 could effectively suppress the mRNA levels of IL-6, IL-1β, iNOS and TNF-α induced by lipopolysaccharide (LPS) Conclusion: We showed that a newly synthesized compound, CP-07, could effectively reduce the inflammatory responses in LPS-stimulated BV2 cells and primary mouse microglia, and overproduction of cytokines in middle cerebral artery occlusion mouse models by inhibiting STAT3 phosphorylation, leading to a neuroprotective effect on I/R brain injury.
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