Evidence map›Paper›PMID 37408264›Full record

ArticleCells2023

Reconsidering Dogmas about the Growth of Bacterial Populations.

Bettina Ughy, Sarolta Nagyapati, Dezi B Lajko, Tamas Letoha, Adam Prohaszka, Dima Deeb, Andras Der, Aladar Pettko-Szandtner, Laszlo Szilak

Open access · goldAbstract read
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Bettina UghyInstitute of Plant Biology, Biological Research Centre, Eötvös Loránd Research Network, H-6726 Szeged, Hungary.
Sarolta NagyapatiInstitute of Plant Biology, Biological Research Centre, Eötvös Loránd Research Network, H-6726 Szeged, Hungary.ORCID 0000-0002-2818-3537
Dezi B LajkoInstitute of Plant Biology, Biological Research Centre, Eötvös Loránd Research Network, H-6726 Szeged, Hungary.ORCID 0000-0002-9922-4367
Tamas LetohaPharmacoIdea Ltd., H-6726 Szeged, Hungary.ORCID 0000-0002-6035-4009
Adam ProhaszkaInstitute of Plant Biology, Biological Research Centre, Eötvös Loránd Research Network, H-6726 Szeged, Hungary.ORCID 0000-0002-2390-2387
Dima DeebInstitute of Plant Biology, Biological Research Centre, Eötvös Loránd Research Network, H-6726 Szeged, Hungary.ORCID 0000-0003-0448-9926
Andras DerInstitute of Biophysics, Biological Research Centre, Eötvös Loránd Research Network, H-6726 Szeged, Hungary.ORCID 0000-0001-6112-884X
Aladar Pettko-SzandtnerLaboratory of Proteomic Research, Biological Research Centre, Eötvös Loránd Research Network, H-6726 Szeged, Hungary.
Laszlo SzilakInstitute of Plant Biology, Biological Research Centre, Eötvös Loránd Research Network, H-6726 Szeged, Hungary.ORCID 0000-0003-0334-272X
HUN-REN Szegedi Biológiai Kutatóközpont · HUUniversity of Szeged · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The growth of bacterial populations has been described as a dynamic process of continuous reproduction and cell death. However, this is far from the reality. In a well fed, growing bacterial population, the stationary phase inevitably occurs, and it is not due to accumulated toxins or cell death. A population spends the most time in the stationary phase, where the phenotype of the cells alters from the proliferating ones, and only the colony forming unit (CFU) decreases after a while, not the total cell concentration. A bacterial population can be considered as a virtual tissue as a result of a specific differentiation process, in which the exponential-phase cells develop to stationary-phase cells and eventually reach the unculturable form. The richness of the nutrient had no effect on growth rate or on stationary cell density. The generation time seems not to be a constant value, but it depended on the concentration of the starter cultures. Inoculations with serial dilutions of stationary populations reveal a so-called minimal stationary cell concentration (MSCC) point, up to which the cell concentrations remain constant upon dilutions; that seems to be universal among unicellular organisms.

Indexed as

Cell DivisionCytokinesisSynechococcusBacterial ProteinsBatch Cell Culture TechniquesCulture MediaProteomicsBacterial ProteinsCulture Mediadifferentiationexponential phasegeneration timepopulation growthproteomicsstationary phasetransition

Identifiers

PMID37408264
PMCPMC10217356
OpenAlexW4377293116

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.