Evidence map›Paper›PMID 37408238›Full record

ArticleCells2023

Tissue-Specific Vulnerability to Apoptosis in Machado-Joseph Disease.

Ana F Ferreira, Mafalda Raposo, Emily D Shaw, Naila S Ashraf, Filipa Medeiros, Maria de Fátima Brilhante, Matthew Perkins, João Vasconcelos, Teresa Kay, Maria do Carmo Costa and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Ana F FerreiraFaculdade de Ciências e Tecnologia, Universidade dos Açores, 9500-321 Ponta Delgada, Portugal.ORCID 0000-0001-9839-3364
Mafalda RaposoInstituto de Biologia Molecular e Celular (IBMC), Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, 4200-135 Porto, Portugal.
Emily D ShawDepartment of Neurology, Michigan Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Naila S AshrafDepartment of Neurology, Michigan Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Filipa MedeirosFaculdade de Ciências e Tecnologia, Universidade dos Açores, 9500-321 Ponta Delgada, Portugal.
Maria de Fátima BrilhanteFaculdade de Ciências e Tecnologia, Universidade dos Açores, 9500-321 Ponta Delgada, Portugal.ORCID 0000-0001-9276-7011
Matthew PerkinsDepartment of Neurology, Michigan Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
João VasconcelosServiço de Neurologia, Hospital do Divino Espírito Santo (HDES), 9500-370 Ponta Delgada, Portugal.
Teresa KayServiço de Genética Clínica, Hospital D. Estefânia, 1169-045 Lisboa, Portugal.
Maria do Carmo CostaDepartment of Neurology, Michigan Medicine, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-8466-4864
Manuela LimaFaculdade de Ciências e Tecnologia, Universidade dos Açores, 9500-321 Ponta Delgada, Portugal.ORCID 0000-0002-3357-3273
Michigan Medicine · USUniversidade dos Açores · PTHospital de Dona Estefânia · PTHospital do Divino Espírito Santo · PTi3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Machado-Joseph disease (MJD) is a dominant neurodegenerative disease caused by an expanded CAG repeat in the

Indexed as

Machado-Joseph DiseaseNeurodegenerative DiseasesAnimalsApoptosisbcl-2-Associated X ProteinFollow-Up StudiesMiceMice, Transgenicbcl-2-Associated X Proteinataxin-3ATXN3biomarkershuman brainsmitochondrial apoptosisMJDpolyglutamine diseaseSCA3spinocerebellar ataxia type 3transgenic mice

Identifiers

PMID37408238
PMCPMC10216795
OpenAlexW4377103049

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.