Evidence map›Paper›PMID 37407839›Full record

ReviewCellular and molecular life sciences : CMLS2023

The emerging roles of long noncoding RNAs in lymphatic vascular development and disease.

Konstantin I Ivanov, Olga V Samuilova, Andrey A Zamyatnin

Open access · hybridAbstract readReview
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. mCellular and molecular life sciences : CMLS · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 3 countries.

Konstantin I IvanovResearch Center for Translational Medicine, Sirius University of Science and Technology, Sochi, Russian Federation. konstantin.i.ivanov@gmail.com.ORCID http://orcid.org/0000-0001-9198-5674
Olga V SamuilovaDepartment of Biochemistry, Sechenov First Moscow State Medical University, Moscow, Russian Federation.ORCID http://orcid.org/0000-0002-1195-9116
Andrey A ZamyatninResearch Center for Translational Medicine, Sirius University of Science and Technology, Sochi, Russian Federation.ORCID http://orcid.org/0000-0002-3046-4565
Lomonosov Moscow State University · RUNational Research University Higher School of Economics · RUUniversity of Helsinki · FI

Funding

Russian Science Foundation 21-75-30020
6 · The paper itself

Abstract

Recent advances in RNA sequencing technologies helped uncover what was once uncharted territory in the human genome-the complex and versatile world of long noncoding RNAs (lncRNAs). Previously thought of as merely transcriptional "noise", lncRNAs have now emerged as essential regulators of gene expression networks controlling development, homeostasis and disease progression. The regulatory functions of lncRNAs are broad and diverse, and the underlying molecular mechanisms are highly variable, acting at the transcriptional, post-transcriptional, translational, and post-translational levels. In recent years, evidence has accumulated to support the important role of lncRNAs in the development and functioning of the lymphatic vasculature and associated pathological processes such as tumor-induced lymphangiogenesis and cancer metastasis. In this review, we summarize the current knowledge on the role of lncRNAs in regulating the key genes and pathways involved in lymphatic vascular development and disease. Furthermore, we discuss the potential of lncRNAs as novel therapeutic targets and outline possible strategies for the development of lncRNA-based therapeutics to treat diseases of the lymphatic system.

Indexed as

NeoplasmsRNA, Long NoncodingGene Expression Regulation, NeoplasticGene Regulatory NetworksHumansRNA, Long NoncodingGene regulationlncRNALong non-coding RNALymphatic endothelial cells (LECs)LymphaticsLymphatic vesselsLymph node metastasis (LNM)Regulation of gene expression

Identifiers

PMID37407839
PMCPMC10322780
OpenAlexW4383197918

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.