ArticleScientific reports2023
An attempt to model the causal structure behind white matter aging and cognitive decline.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Article
- MRI resting-state signature of the propensity to experience meaningful coincidences: a functional coupling analysis.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Distinct Longitudinal Brain White Matter Microstructure Changes and Associated Polygenic Risk of Common Psychiatric Disorders and Alzheimer's Disease in the UK Biobank.Biological psychiatry global open science · 2024Article
- When most fMRI connectivity cannot be detected: Insights from time course reliability.PloS one · 2024Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
In this diffusion tension imaging study, voxel wise structural equation modeling was used to unravel the relation between white matter, cognition, and age. Four neurocognitive ageing models describing the interplay between age, white matter integrity, and cognition were investigated but only two models survived an Akaike information criterion-based model selection procedure. The independent factor model predicts that there is no relation between white matter integrity and cognition although both systems are affected by age. The cognitive mediation model predicts that the relation between age and white matter integrity is mediated through cognition. Roughly 60% of the observed voxels were in agreement with the independent factor model while 16% of the observed voxels were in agreement with the cognitive mediation model. Imaging results of the latter model suggest that the deterioration of fibers-that connect the two hemispheres with each other-is partly caused by an age-related decline in cognitive functioning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.