Evidence map›Paper›PMID 37407501›Full record

ArticleBrain and behavior2023

Lipopolysaccharide-induced sickness behavior is not altered in male Fmr1-deficient mice.

Danielle Santana-Coelho, Samantha L Hodges, Saul I Quintero, Paige D Womble, D Greg Sullens, David A Narvaiz, Rebecca Herrera, Melanie J Sekeres, Joaquin N Lugo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Neonatal immune stimulation results in sex-specific changes in ultrasonic vocalizations but does not affect seizure susceptibility in neonatal mice.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2024
    Article
  6. Clockwork intruders: Do parasites manipulate their hosts' circadian rhythms?Current research in parasitology & vector-borne diseases · 2024
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Danielle Santana-CoelhoDepartment of Psychology and Neuroscience, Baylor University, Waco, Texas, USA.
Samantha L HodgesInstitute of Biomedical Studies, Baylor University, Waco, Texas, USA.
Saul I QuinteroDepartment of Psychology and Neuroscience, Baylor University, Waco, Texas, USA.
Paige D WombleDepartment of Psychology and Neuroscience, Baylor University, Waco, Texas, USA.
D Greg SullensDepartment of Psychology and Neuroscience, Baylor University, Waco, Texas, USA.ORCID 0000-0002-6426-2355
David A NarvaizDepartment of Psychology and Neuroscience, Baylor University, Waco, Texas, USA.
Rebecca HerreraDepartment of Psychology and Neuroscience, Baylor University, Waco, Texas, USA.
Melanie J SekeresDepartment of Psychology and Neuroscience, Baylor University, Waco, Texas, USA.
Joaquin N LugoDepartment of Psychology and Neuroscience, Baylor University, Waco, Texas, USA.ORCID 0000-0001-6874-8718
Baylor University · US

Funding

Signaling Mechanisms Underlying Epilepsy and Autism CormorbidityR15NS088776 · NINDS · BAYLOR UNIVERSITY · PI JOAQUIN N LUGO · 2015 to 2026
$1.8M
NINDS NIH HHS R15 NS088776
6 · The paper itself

Abstract

objectivesFragile X syndrome is the main monogenetic cause of intellectual disability and autism. Alterations in the immune system are commonly found in these developmental disorders. We and others have demonstrated that Fmr1 mutant mice present an altered response to immune stimuli. However, whether this altered immune response can influence the Fmr1 mutant behavioral outcomes in response to inflammation has not been fully investigated. MATERIALS AND

methodsIn the current study, we examine the behavioral sickness response of male wildtype and knockout  mice to the innate immune stimulus lipopolysaccharide (LPS) (0.1 mg/kg) to determine if Fmr1 mutants have altered sickness behavior. We used an enzyme-linked immunosorbent assay (ELISA) to measure changes in the cytokine interleukin-6 (IL-6) to determine that inflammation was induced in the mice. Sickness behavior was assessed in a wheel-running paradigm, and a tail suspension test was used to assess the depressive-like phenotype that follows sickness behavior in response to LPS.

resultsThe ELISA using blood serum confirmed a significant increase in IL-6 in mice that were treated with LPS. Treated Fmr1 mutants exhibited decreased distance traveled in the wheel running after LPS administration, similar to treated controls. Another cohort of animals treated with LPS were tested in the tail suspension test and exhibited no alterations in immobility time in response to LPS.

conclusionTogether, our data suggest that Fmr1 mutant mice do not have altered sickness behavior in response to a low dose of LPS.

Indexed as

Fragile X Messenger Ribonucleoprotein 1Illness BehaviorAnimalsBehavior, AnimalDepressionDisease Models, AnimalInflammationInterleukin-6LipopolysaccharidesMaleMiceMice, KnockoutMotor ActivityFmr1 protein, mouseFragile X Messenger Ribonucleoprotein 1Interleukin-6Lipopolysaccharidesfragile X syndromelipopolysaccharidesickness behaviortail suspensionwheel running

Identifiers

PMID37407501
PMCPMC10454339
OpenAlexW4383196896

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.